High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients.
High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients.
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入院时天冬氨酸转氨酶与丙氨酸转氨酶比率高是 COVID-19 患者预后不良的危险因素
DOI：
10.1038/s41598-020-73575-2
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发表时间：
2020-10-05
影响因子：
4.6
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Qin C;Wei Y;Lyu X;Zhao B;Feng Y;Li T;Cao H;Yang X;Zhou X;Wang W;You L;Wang Y
本研究旨在分析COVID-19患者的天冬氨酸氨基转移酶（AST）与丙氨酸氨基转移酶（ALT）比值。排除后，567例住院患者纳入本研究，并根据其入院时的AST/ALT比值分为两组。本研究中死亡被视为预后不良。567例患者中，200例（35.3%）AST/ALT ≥ 1.38。在200例患者中，年龄较大（中位年龄60岁）、肌痛（64例[32%]病例）、疲劳（91例[45.5%]病例）、一些合并症和结局与AST/ALT < 1.38的患者有显著差异。他们的胸部计算机断层扫描（CT）结果、实验室检查结果和严重程度评分也更差。血小板计数（OR 0.995，95% CI [0.992-0.998]）和血红蛋白（OR 0.984，95% CI [0.972-0.995]）水平与入院时AST/ALT ≥ 1.38独立相关。此外，入院时AST/ALT比值高是预后不良的独立危险因素（OR 99.9，95% CI [2.1-4280.5]）。在随后的监测中，幸存者和非幸存者在住院期间均显示AST/ALT比值下降。总之，高AST/ALT比值可能是COVID-19患者病情和结局恶化的指征。
This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Death was regarded as poor prognosis in this study. Of 567 patients, 200 (35.3%) had AST/ALT ≥ 1.38. Of the 200 patients, older age (median age 60 years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes were significantly different from patients with AST/ALT < 1.38. They also had worse chest computed tomography (CT) findings, laboratory results and severity scores. Levels of platelet count (OR 0.995, 95% CI [0.992–0.998]) and hemoglobin (OR 0.984, 95% CI [0.972–0.995]) were independently associated with AST/ALT ≥ 1.38 on admission. Furthermore, a high AST/ALT ratio on admission was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1–4280.5]). In subsequent monitoring, both survivors and non-survivors showed decreased AST/ALT ratio during hospitalization. In conclusion, high AST/ALT ratio might be the indication of worse status and outcomes in COVID-19 patients.
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影响因子：
2.1
作者：
Wang, Jinxin;Li, Jiawen;Qiu, Huixian
通讯作者：
Qiu, Huixian
影响因子：
4.9
作者：
Riedl, Jakob Michael;Posch, Florian;Gerger, Armin
通讯作者：
Gerger, Armin
DOI：
10.1016/j.cimid.2007.05.009
发表时间：
2007-09
期刊：
Comparative immunology, microbiology and infectious diseases
影响因子：
--
作者：
Feng Y;Gao GF
通讯作者：
Gao GF
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影响因子：
120.7
作者：
Wang, Dawei;Hu, Bo;Peng, Zhiyong
通讯作者：
Peng, Zhiyong
影响因子：
158.5
作者：
Guan, W.;Ni, Z.;Zhong, N.
通讯作者：
Zhong, N.