Obesity-mediated inflammation may damage the brain circuit that regulates food intake.
Obesity-mediated inflammation may damage the brain circuit that regulates food intake.
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DOI：
10.1016/j.brainres.2010.12.008
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发表时间：
2011-02-10
期刊：
影响因子：
2.9
通讯作者：
Convit A
中科院分区：
文献类型：
--
作者：
Cazettes F;Cohen JI;Yau PL;Talbot H;Convit A
肥胖与慢性低度全身炎症和下丘脑炎症增加有关，下丘脑是进食行为的关键结构。目前尚不清楚炎症是否会影响调节进食行为的其他大脑结构。我们研究了 44 名超重/肥胖者和 19 名瘦人的 MRI 和血浆纤维蛋白原水平（炎症标志物）。我们对内侧和外侧眶额皮质 (OFC) 和海马体积进行了基于 MRI 的分割。灰质（GM）体积根据头部大小的变化进行调整。我们进行逻辑回归和层次回归来评估纤维蛋白原水平和脑体积数据之间的关联。使用扩散张量成像 (DTI)，我们创建了表观扩散系数 (ADC) 图并进行了体素相关分析。超重/肥胖者的纤维蛋白原浓度较高（t[61]=-2.33，P=0.023）。与纤维蛋白原相关的侧向 OFC 正确分类了体重超重的患者（准确度 = 76.2%，敏感性 = 95.5%，特异性 = 31.6%）。超重/肥胖的外侧 OFC 体积与纤维蛋白原呈负相关（r=-0.37，P=0.016），在考虑了年龄、高血压、腰臀比以及脂质和糖水平后，纤维蛋白原显着解释了外侧 OFC 体积的额外 9% 方差（β=-0.348，ΔR2=0.093，ΔF P=0.046）。在超重/肥胖人群中，GM ADC 与纤维蛋白原之间的关联在左右杏仁核和右侧顶叶区域呈显着正相关（P<0.001）。在瘦人中，这些关联呈负相关，并且位于左前额叶、右顶叶和左枕叶。这是第一项研究表明，与肥胖相关的炎症可能会降低某些参与奖励和进食行为的大脑结构的完整性。
Adiposity is associated with chronic low-grade systemic inflammation and increased inflammation in the hypothalamus, a key structure in feeding behavior. It remains unknown whether inflammation impacts other brain structures that regulate feeding behavior. We studied 44 overweight/obese and 19 lean individuals with MRI and plasma fibrinogen levels (marker of inflammation). We performed MRI-based segmentations of the medial and lateral orbitofrotal cortex (OFC) and hippocampal volumes. Gray matter (GM) volumes were adjusted for head size variability. We conducted logistic and hierarchical regressions to assess the association between fibrinogen levels and brain volumetric data. Using diffusion tensor imaging (DTI), we created apparent diffusion coefficient (ADC) maps and conducted voxelwise correlational analyses. Fibrinogen concentrations were higher among the overweight/obese (t[61]=-2.33, P=0.023). Lateral OFC associated together with fibrinogen correctly classified those with excess of weight (accuracy=76.2%, sensitivity=95.5%, specificity=31.6%). The lateral OFC volumes of overweight/obese were negatively associated with fibrinogen (r=-0.37, P=0.016) and after accounting for age, hypertension, waist/hip ratio and lipid and sugar levels, fibrinogen significantly explained an additional 9% of the variance in the lateral OFC volume (β=-0.348, ΔR2=0.093, ΔF P=0.046). Among overweight/obese the associations between GM ADC and fibrinogen were significantly positive (P<0.001) in the left and right amygdala and the right parietal region. Among lean individuals these associations were negative and located in the left prefrontal, the right parietal and the left occipital lobes. This is the first study to report that adiposity-related inflammation may reduce the integrity of some of the brain structures involved in reward and feeding behaviors.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
3.3
作者：
Machado, C. J.;Bachevalier, J.
通讯作者：
Bachevalier, J.
影响因子：
7.7
作者：
Levin, BE;Routh, VH;Dunn-Meynell, AA
通讯作者：
Dunn-Meynell, AA
DOI：
10.1038/oby.2000.33
发表时间：
2000-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Duncan, BB;Schmidt, MI;Heiss, G
通讯作者：
Heiss, G
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y