Scaling Principles of White Matter Connectivity in the Human and Nonhuman Primate Brain.
Scaling Principles of White Matter Connectivity in the Human and Nonhuman Primate Brain.
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DOI：
10.1093/cercor/bhab384
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发表时间：
2022-06-16
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影响因子：
--
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大脑有很多形状和大小。大自然赋予了像人类这样的大脑灵长类动物相应的大大脑皮层。然而，比较研究表明，分配给白色物质连接的总体积大脑进行远距离区域间通信的基础设施并没有跟上皮层的步伐。我们研究了这种异速生长缩放对大脑连接和网络组织的影响。我们整理了14种灵长类动物的结构和弥散磁共振成像数据，描述了不同物种大脑大小的350倍范围。我们展示了体积缩放关系，确实指向更大的大脑中宏观尺度连接的限制。我们报告皮质表面积超过了白色物质的体积，更大的大脑显示出更低的整体连通性水平，特别是通过稀疏的长距离连接。我们发现，这些白色物质连接的限制与更长的通信路径，更高的本地网络集群，以及更高水平的不对称性在同源区域之间的连接模式在左，右半球。我们的研究结果揭示了主要大脑成分的保守比例关系，并显示了宏观大脑回路的后果，为更大的大脑（如人脑）中预期的连接体结构提供了见解。
Brains come in many shapes and sizes. Nature has endowed big-brained primate species like humans with a proportionally large cerebral cortex. Comparative studies have suggested, however, that the total volume allocated to white matter connectivity—the brain’s infrastructure for long-range interregional communication—does not keep pace with the cortex. We investigated the consequences of this allometric scaling on brain connectivity and network organization. We collated structural and diffusion magnetic resonance imaging data across 14 primate species, describing a comprehensive 350-fold range in brain size across species. We show volumetric scaling relationships that indeed point toward a restriction of macroscale connectivity in bigger brains. We report cortical surface area to outpace white matter volume, with larger brains showing lower levels of overall connectedness particularly through sparser long-range connectivity. We show that these constraints on white matter connectivity are associated with longer communication paths, higher local network clustering, and higher levels of asymmetry in connectivity patterns between homologous areas across the left and right hemispheres. Our findings reveal conserved scaling relationships of major brain components and show consequences for macroscale brain circuitry, providing insights into the connectome architecture that could be expected in larger brains such as the human brain.
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影响因子：
10.6
作者：
Francis AN;Mothi SS;Mathew IT;Tandon N;Clementz B;Pearlson GD;Sweeney JA;Tamminga CA;Keshavan MS
通讯作者：
Keshavan MS
DOI：
10.1073/pnas.1201898109
发表时间：
2012-06-26
影响因子：
11.1
作者：
Barrett, H. Clark
通讯作者：
Barrett, H. Clark
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
6.7
作者：
Cabeen RP;Glass L;Erwin JM;Hof PR;Toga AW;Allman JM
通讯作者：
Allman JM
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC