The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study.
The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study.
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DOI：
10.1016/j.pneurobio.2020.101941
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发表时间：
2020-12
影响因子：
6.7
通讯作者：
Allman JM
中科院分区：
文献类型：
--
作者：
Cabeen RP;Glass L;Erwin JM;Hof PR;Toga AW;Allman JM
我们映射的岛屿冯Economo神经元（VEN）区域的连接在离体的倭黑猩猩，猩猩和两个大猩猩的大脑与高角分辨率的扩散MRI成像在36小时的成像会议中获得的每个大脑。这些猿类是自然死亡的，没有神经系统疾病。岛叶VEN区域的定位基于每个脑的甲酚紫染色组织切片，其与来自相同个体的结构和扩散图像共配准。弥散磁共振纤维束成像显示，岛叶VEN区与嗅觉，味觉，视觉和其他感觉系统，以及食欲，奖励，厌恶和动机的调解系统。类人猿的岛状VEN区与额极皮层的联系最为密切，这可以支持它们在各种行动方案中自愿选择的能力，特别是在探索食物资源时。额极皮层也可能支持他们记录未来可能收获的资源的能力（前瞻性记忆）。所有这些能力都可以支持洞察力和意志选择，而不是基于规则的决策。
We mapped the connections of the insular von Economo neuron (VEN) area in ex vivo brains of a bonobo, an orangutan and two gorillas with high angular resolution diffusion MRI imaging acquired in 36 hour imaging sessions for each brain. The apes died of natural causes without neurological disorders. The localization of the insular VEN area was based on cresyl violet-stained histological sections from each brain that were coregistered with structural and diffusion images from the same individuals. Diffusion MRI tractography showed that the insular VEN area are connected with olfactory, gustatory, visual and other sensory systems, as well as systems for the mediation of appetite, reward, aversion and motivation. The insular VEN area in apes is most strongly connected with frontopolar cortex, which could support their capacity to choose voluntarily among alternative courses of action particularly in exploring for food resources. The frontopolar cortex may also support their capacity to take note of potential resources for harvesting in the future (prospective memory). All of these faculties may support insight and volitional choice when contemplating courses of action as opposed to rule-based decision-making.
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影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
2.4
作者：
Chau, Aileen;Salazar, Andres M.;Grafman, Jordan
通讯作者：
Grafman, Jordan
影响因子：
16.2
作者：
Boorman, Erie D.;Behrens, Timothy E. J.;Rushworth, Matthew F. S.
通讯作者：
Rushworth, Matthew F. S.
影响因子：
2.5
作者：
GIGUERE, M;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC