Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes.
Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes.
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DOI：
10.1016/j.biopsych.2015.12.026
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发表时间：
2016-10-15
影响因子：
10.6
通讯作者：
Keshavan MS
中科院分区：
文献类型：
--
作者：
Francis AN;Mothi SS;Mathew IT;Tandon N;Clementz B;Pearlson GD;Sweeney JA;Tamminga CA;Keshavan MS
胼胝体（CC）与精神分裂症和双相情感障碍的发病机制有关。然而，目前尚不清楚CC的改变是否与精神障碍的潜在家族性素质有关。我们在精神分裂症（SZ）、精神病性双相情感障碍（PBD）、分裂情感障碍（SZA）、他们的一级亲属和健康对照者中研究了CC、它的子区域量，以及它们与认知、精神病症状和年龄的关系。我们报告了对1429名受试者[SZ (n=224), PBD (n=190), SZA (n=142)，未受影响亲属n= 483) [SZ亲属（195），PBD亲属（175），SZA亲属（113）]和对照组（n=342）]的形态测量学和神经认知分析结果。MPRAGE T1扫描在5个地点使用3。T磁铁。图像处理使用FreeSurfer 5.1完成。神经认知功能采用精神分裂症认知简要评估（BACS）进行测量。各组脾前、后体积均显著减小。SZ和PBD先证者表现出强劲而显著的减少，而亲属表现出中度严重程度的显著减少。先证者及其亲属的脾体积与认知各方面呈正相关，但存在差异。先证者组与对照组相比，脾前体积明显与年龄相关。在精神病组中，PANSS显示PBD的前脾与精神病症状有较强的相关性。所有五个次区域都表现出明显的高熟悉度。脾体积在整个精神病维度上明显减小。然而，这种体积减少对疾病的认知和临床表现的影响是不同的。
The corpus callosum (CC) has been implicated in the pathogenesis of schizophrenia and bipolar disorder. Yet, it remains unclear whether CC alterations are related to the underlying familial diathesis for psychotic disorders. We examined CC, its sub-region volumes, and their relationship to cognition, psychotic symptoms and age in subjects with schizophrenia (SZ), psychotic bipolar disorder (PBD), schizoaffective disorder (SZA), their first-degree relatives and in healthy controls. We present findings from morphometric and neurocognitive analyses of 1429 subjects [SZ (n=224), PBD (n=190), SZA (n=142), unaffected relatives n= 483) [SZ relatives (195), PBD relatives (175), SZA relatives (113)], and Controls (n=342)]. MPRAGE T1 scans across 5 sites were obtained using 3.T magnets. Image processing was done using FreeSurfer 5.1. Neurcognitive function was measured using the Brief Assessment of Cognition in Schizophrenia (BACS). Anterior and posterior splenia volumes were significantly reduced across the groups. SZ and PBD Probands showed robust and significant reductions while relatives showed significant reductions of intermediate severity. The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives. Proband groups showed a significant age-related decrease in the volume of the anterior splenium in comparison with controls. Among the psychosis groups, the anterior splenium in PBD showed a stronger correlation with psychotic symptomatology as shown by the PANSS. All five sub regions showed significantly high familiality. The splenial volumes were significantly reduced across the psychosis dimension. However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.
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影响因子：
6.6
作者：
Arnold, Sara J. M.;Ivleva, Elena I.;Tamminga, Carol A.
通讯作者：
Tamminga, Carol A.
影响因子：
1.9
作者：
HINES, M;MCADAMS, LA;LIPCAMON, J
通讯作者：
LIPCAMON, J
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon
影响因子：
5.7
作者：
Fornari, Eleonora;Knyazeva, Maria G.;Maeder, Philippe
通讯作者：
Maeder, Philippe