Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling.
Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling.
复制标题
白介素13在皮肤中的转基因表达诱导核皮炎和皮肤重塑。
DOI：
10.1038/jid.2008.295
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
IL-13 has been implicated in the pathogenesis of allergic diseases, including atopic dermatitis (AD). However, a direct role of IL-13 in AD has not been established. We aimed to develop an inducible transgenic model in which IL-13 can be expressed in the skin and to define the resulting dermal phenotype and mechanisms involved. The keratin 5 promoter was used with a tetracycline-inducible system to target IL-13 to the skin. The clinical manifestations, dermal histology, cytokine gene regulation, and systemic immune responses in the transgenic mice were assessed. IL-13 was produced exclusively in the skin and caused a chronic inflammatory phenotype characterized by xerosis and pruritic eczematous lesions; dermal infiltration of CD4 + T cells, mast cells, eosinophils, macrophages, and Langerhans cells; upregulation of chemokine and cytokine genes, including thymic stromal lymphopoietin; and skin remodeling with fibrosis and increased vasculature. The dermal phenotype was accompanied by elevated serum total IgE and IgG1 and increased production of IL-4 and IL-13 by CD4 + cells from lymphoid tissues and peripheral blood mononuclear cells. IL-13 is a potent stimulator of dermal inflammation and remodeling and this transgenic model of AD is a good tool for investigating the underlying mechanisms in the pathogenesis of AD.
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影响因子：
4.4
作者：
Nomura, I;Goleva, E;Leung, DYM
通讯作者：
Leung, DYM
影响因子：
6.5
作者：
Diamond, I;Owolabi, T;Glick, A
通讯作者：
Glick, A
影响因子：
14.2
作者：
Novak, N;Kraft, S;Bieber, T
通讯作者：
Bieber, T
DOI：
10.1084/jem.20051745
发表时间：
2006-02-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Liu YJ
通讯作者：
Liu YJ
影响因子：
14.2
作者：
LEUNG, DYM;HIRSCH, RL;HANIFIN, JM
通讯作者：
HANIFIN, JM