Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide.
Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide.
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DOI：
10.1186/1742-2094-8-179
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发表时间：
2011-12-21
影响因子：
9.3
通讯作者：
McCusker RH
中科院分区：
文献类型：
--
作者：
Park SE;Lawson M;Dantzer R;Kelley KW;McCusker RH
中心给药的胰岛素样生长因子-I在几种啮齿动物模型中具有抗抑郁活性，包括脂多糖(LPS)诱导的抑郁。在这项研究中，我们测试了IGF-I和GPE(源于IGF-I的N端三肽)改变腹膜腔内(I.P.)诱导的抑郁样行为的能力。以预防和治疗的方式给予内毒素。第1组给予胰岛素样生长因子-I(1μg)或GPE(5μg)静脉滴注。30min后给CD-1小鼠灌胃330μg/kg体重。LP。另一组在胰岛素样生长因子-I或GPE前24小时给予脂多糖830μg/kg体重。当接受腹腔注射时，内毒素引起的全面疾病被评估为体重减轻、食物摄入量减少和疾病行为。这些指标均不受IGF-I或GPE的影响。脂多糖还会导致类似抑郁的行为；评估为尾部悬挂和强迫游泳测试中不动时间的延长。当在脂多糖之前或之后给药时，IGF-I和GPE消除了内毒素的反应；减弱了抑郁样行为的诱导，并阻止了先前存在的抑郁样行为。与以前研究IGF-I的工作类似，GPE减少了脑组织细胞因子的表达以应对内毒素，但与IGF-I不同的是，GPE不诱导脑源性神经营养因子(BDNF)的表达。脂多糖诱导色氨酸双加氧酶、IDO_1、IDO_2和TDO_2的表达，但GPE不影响这些酶的表达。因此，IGF-I和GPE都能在不受疾病影响的抑郁症样行为中诱导特定的改善，这一作用可能是由于它们的抗炎特性。
Centrally administered insulin-like growth factor (IGF)-I has anti-depressant activity in several rodent models, including lipopolysaccharide (LPS)-induced depression. In this study we tested the ability of IGF-I and GPE (the N-terminal tri-peptide derived from IGF-I) to alter depression-like behavior induced by intraperitoneal (i.p.) administration of LPS in a preventive and curative manner. In the first case, IGF-I (1 μg) or GPE (5 μg) was administered i.c.v. to CD-1 mice followed 30 min later by 330 μg/kg body weight i.p. LPS. In the second case, 830 μg/kg body weight LPS was given 24 h prior to either IGF-I or GPE. When administered i.p., LPS induced full-blown sickness assessed as a loss of body weight, decrease in food intake and sickness behavior. None of these indices were affected by IGF-I or GPE. LPS also induced depression-like behavior; assessed as an increased duration of immobility in the tail suspension and forced swim tests. When administered before or after LPS, IGF-I and GPE abrogated the LPS response; attenuating induction of depression-like behaviors and blocking preexistent depression-like behaviors. Similar to previous work with IGF-I, GPE decreased brain expression of cytokines in response to LPS although unlike IGF-I, GPE did not induce the expression of brain-derived neurotrophic factor (BDNF). LPS induced expression of tryptophan dioxygenases, IDO1, IDO2 and TDO2, but expression of these enzymes was not altered by GPE. Thus, both IGF-I and GPE elicit specific improvement in depression-like behavior independent of sickness, an action that could be due to their anti-inflammatory properties.
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影响因子：
2.7
作者：
Duman, Catharine H.;Schlesinger, Lee;Terwilliger, Rosemarie;Russell, David S.;Newton, Samuel S.;Duman, Ronald S.
通讯作者：
Duman, Ronald S.
影响因子：
25
作者：
Damasio, AR;Grabowski, TJ;Hichwa, RD
通讯作者：
Hichwa, RD
影响因子：
3.7
作者：
Frenois, Francois;Moreau, Maite;Castanon, Nathalie
通讯作者：
Castanon, Nathalie
影响因子：
3.3
作者：
Burgdorf, J.;Kroes, R. A.;Moskal, J. R.
通讯作者：
Moskal, J. R.
影响因子：
--
作者：
Aberg ND;Brywe KG;Isgaard J
通讯作者：
Isgaard J