Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China.
Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China.
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DOI：
10.3389/fmicb.2023.1215428
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
黄曲霉毒素 (AFT) 被确定为 1 类人类致癌物，天然会污染各种类型的食物，并可能通过饮食摄入增加患肝细胞癌 (HCC) 的风险。重庆市地处中国西南地区，属亚热带季风气候，有利于农作物AFT污染。然而，重庆人群膳食暴露AFT造成的HCC负担尚未量化。使用 FDA-iRISK 软件根据伤残调整生命年 (DALY) 估算 HCC 的负担。评估了三种食品类别中 AFT 的膳食暴露，包括谷物及其制品、坚果和种子以及香料。在平均和重度 (P95) AFT 污染水平下，人群 AFT 暴露的终生平均日剂量 (LADD) 范围分别为 2.40 至 8.25 ng/kg bw/天和 9.51 至 15.10 ng/kg bw/天。在三类食品中，粮食及其制品对人群AFT暴露的贡献最大。与 AFT 诱发的 HCC 相关的估计 DALY 为 162,000-556,000 和 641,000-1,020,000； DALY 比率为每年每 10 万人 6.47-22.20 和 25.59-40.72；群体归因分数（PAF）为1.68-5.78%和6.66-10.60%。尽管膳食 AFT 造成的 HCC 负担在人群中估计相对较低，但由于该数据集的不确定性，总体健康负担可能被低估。因此，与 AFT 摄入相关的总体健康负担仍应在进一步的研究中受到关注。
Aflatoxins (AFT) identified as a Group 1 human carcinogen naturally contaminate various types of food and could increase the risk of hepatocellular carcinoma (HCC) through dietary intake. Chongqing municipality is located in Southwest China with subtropical monsoon climate which is conducive to AFT contamination in crops. However, the burden of HCC caused by the dietary exposure of the population in Chongqing to AFT has not been quantified. The burden of HCC was estimated in terms of Disability Adjusted Life Year (DALY) using FDA-iRISK software. Dietary exposure to AFT in three food categories including grain and its products, nuts and seeds, and spices was assessed. The lifetime average daily dose (LADD) of AFT exposure for the population ranged from 2.40 to 8.25 ng/kg bw/day and 9.51 to 15.10 ng/kg bw/day at the mean and heavy (P95) AFT contamination levels, respectively. Among the three food categories, grain and its products contributed most to AFT exposure of the population. The estimated DALYs related to HCC induced by AFT were 162,000–556,000 and 641,000-1,020,000; the DALY rates were 6.47–22.20 and 25.59–40.72 per 100,000 persons per year; and the population attribution fractions (PAF) were 1.68–5.78% and 6.66–10.60%. Although the burden of HCC caused by dietary AFT was estimated to be relatively low among the population, the overall health burden might be underestimated owing to the uncertainties of this dataset. Thus, the overall health burden associated with AFT intake should still be of concern in further studies.
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影响因子：
15.8
作者：
Havelaar AH;Kirk MD;Torgerson PR;Gibb HJ;Hald T;Lake RJ;Praet N;Bellinger DC;de Silva NR;Gargouri N;Speybroeck N;Cawthorne A;Mathers C;Stein C;Angulo FJ;Devleesschauwer B;World Health Organization Foodborne Disease Burden Epidemiology Reference Group
通讯作者：
World Health Organization Foodborne Disease Burden Epidemiology Reference Group
DOI：
10.1080/19393210.2012.713028
发表时间：
2012-01-01
影响因子：
2.9
作者：
Chin, C. K.;Abdullah, A.;Sugita-Konishi, Y.
通讯作者：
Sugita-Konishi, Y.
DOI：
10.1080/19440049.2018.1447691
发表时间：
2018-01-01
影响因子：
2.9
作者：
Assuncao, Ricardo;Martins, Carla;Alvito, Paula
通讯作者：
Alvito, Paula
影响因子：
2
作者：
Chen, Yuhuan;Dennis, Sherri B.;Wilson, Margaret
通讯作者：
Wilson, Margaret
黄曲霉毒素暴露的减少预示着中国肝癌流行地区死亡率的下降。
DOI：
10.1158/1940-6207.capr-13-0168
发表时间：
2013-10
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Chen JG;Egner PA;Ng D;Jacobson LP;Muñoz A;Zhu YR;Qian GS;Wu F;Yuan JM;Groopman JD;Kensler TW
通讯作者：
Kensler TW