Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats.
Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats.
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DOI：
10.1371/journal.pone.0027237
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
McGregor IS
中科院分区：
文献类型：
--
作者：
Bowen MT;Carson DS;Spiro A;Arnold JC;McGregor IS
先前的研究表明，催产素（OT）的施用可以对哺乳动物的社交和焦虑样行为产生调节作用，这种作用可能持续到急性OT施用的时间之后。目前的研究检查了在关键发育时期（青春期早期）对雄性Wistar大鼠（n = 48）重复给予OT是否会改变它们晚年的生理和行为。各组大鼠在青春期早期（出生后[PND] 33-42）腹腔注射1 mg/kg OT或载药。OT治疗引起体重增加的短暂抑制，在停止治疗后迅速恢复。在PND 50时，经OT预处理的大鼠在出现测试中表现出较少的焦虑样行为，而在PND 55时，它们表现出更高水平的社会互动。在PND 63检查的OT预处理大鼠亚组显示出血浆OT水平升高的强烈趋势，下丘脑中OT受体mRNA也显着增加。经OT预处理的大鼠及其对照组在每天70分钟的测试阶段（PND 63起）中表现出类似的啤酒摄入诱导，其中啤酒的酒精浓度在几天内逐渐从0.44%增加到4.44%。然而，当从PND 72开始（成年早期）在他们的家庭笼子里自由地获得啤酒时，在OT预处理的大鼠中，啤酒的消费量而不是水的消费量显着减少。在25天随意饮用啤酒后，给予1 mg/kg的OT“加强剂”，对啤酒摄入量有强烈的急性抑制作用，而不影响水摄入量。总的来说，这些结果表明，在青春期进行外源性OT可以对焦虑、社交能力和饮酒动机产生微妙而持久的影响。这种效应可能反映了大脑OT系统固有的神经可塑性，以及外源性OT上调内源性OT系统的前馈效应。
Previous studies have suggested that administration of oxytocin (OT) can have modulatory effects on social and anxiety-like behavior in mammals that may endure beyond the time of acute OT administration. The current study examined whether repeated administration of OT to male Wistar rats (n = 48) during a key developmental epoch (early adolescence) altered their physiology and behavior in later-life. Group housed rats were given intraperitoneal injections of either 1 mg/kg OT or vehicle during early adolescence (post natal-days [PND] 33–42). OT treatment caused a transient inhibition of body weight gain that recovered quickly after the cessation of treatment. At PND 50, the rats pre-treated with OT displayed less anxiety-like behavior on the emergence test, while at PND 55 they showed greater levels of social interaction. A subgroup of OT pre-treated rats examined at PND 63 showed a strong trend towards increased plasma OT levels, and also displayed significantly increased OT receptor mRNA in the hypothalamus. Rats pre-treated with OT and their controls showed similar induction of beer intake in daily 70 min test sessions (PND 63 onwards) in which the alcohol concentration of beer was gradually increased across days from 0.44% to 4.44%. However, when given ad libitum access to beer in their home cages from PND 72 onwards (early adulthood), consumption of beer but not water was significantly less in the OT pre-treated rats. A “booster” shot of OT (1 mg/kg) given after 25 days of ad libitum access to beer had a strong acute inhibitory effect on beer intake without affecting water intake. Overall these results suggest that exogenous OT administered during adolescence can have subtle yet enduring effects on anxiety, sociability and the motivation to consume alcohol. Such effects may reflect the inherent neuroplasticity of brain OT systems and a feed-forward effect whereby exogenous OT upregulates endogenous OT systems.
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DOI：
10.1111/j.1530-0277.2007.00485.x
发表时间：
2007-11-01
影响因子：
3.2
作者：
Hargreaves, Garth A.;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
影响因子：
5.3
作者：
Bale, TL;Davis, AM;McCarthy, MM
通讯作者：
McCarthy, MM
影响因子：
2.3
作者：
Hargreaves, Garth A.;Monds, Lauren;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
影响因子：
4.8
作者：
Di, S;Tasker, JG
通讯作者：
Tasker, JG
影响因子：
3.4
作者：
Gallate, JE;McGregor, IS
通讯作者：
McGregor, IS