Age-dependent interaction between sex and geographic ultraviolet index in melanoma risk.
Age-dependent interaction between sex and geographic ultraviolet index in melanoma risk.
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DOI：
10.1016/j.jaad.2017.11.049
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发表时间：
2020-05
影响因子：
13.8
通讯作者：
Ziogas A
中科院分区：
文献类型：
--
作者：
Liu-Smith F;Ziogas A
紫外线照射可能不会对不同性别和年龄的黑色素瘤的发展产生同样的影响。这些因素是否以及如何在黑色素瘤风险中相互作用尚不清楚。这项研究试图评估紫外线、性别和年龄之间在黑色素瘤风险中的交互作用。黑色素瘤发病率数据来自42个癌症登记处。地理紫外线指数(UVI)来自当地卫星站。采用负二项回归模型估计各危险因素的影响及其交互作用。性别、紫外线指数和年龄，以及这些因素之间的相互作用与黑色素瘤风险显著相关。在较年轻的人群中，女性是黑色素瘤的独立危险因素，不受环境紫外线暴露的影响。然而，在年龄较大的人群中，女性与紫外线暴露作为危险因素相互作用，显示出保护作用。年龄转换的范围是45-49岁，这与荷尔蒙的剧烈变化有关。性和紫外线之间的相互作用是在生态层面上衡量的。性别和紫外线指数之间的相互作用是年龄相关的。女性是早发性黑色素瘤的独立危险因素，但在年龄较大的人群中，女性也可以预防紫外线相关的黑色素瘤。
UV exposure may not equally impact melanoma development in different sexes and ages. Whether and how these factors interact with each other in melanoma risk is unknown. This study attempts to estimate interactions among UVI, sex and age in melanoma risk. Melanoma incidence data was collected from 42 cancer registries. Geographical UV index (UVI) was collected from local satellite stations. Negative binomial regression models were used to estimate the impact of each risk factor and their interactions. Sex, UVI and age, as well as interactions between any two of these factors were significantly associated with melanoma risk. In younger age groups, the female sex is an independent risk factor for melanoma that is not impacted by ambient UV exposure. In older age groups, however, the female sex interacts with UV exposure as a risk factor, exhibiting a protective effect. The switching age category is 45–49, which correlates with dramatic hormonal changes. the interaction between sex and UVI is measured at an ecological level. The interaction between sex and UVI is age-dependent. The female sex is an independent risk factor for early onset melanoma, but the female sex also protects against UV-associated melanoma in older age groups.
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