Angiopoietin-Like Protein 4 May Be an Interplay Between Serum Uric Acid and Triglyceride-Rich Lipoprotein Cholesterol.
Angiopoietin-Like Protein 4 May Be an Interplay Between Serum Uric Acid and Triglyceride-Rich Lipoprotein Cholesterol.
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血管生成素样蛋白 4 可能是血清尿酸和富含甘油三酯的脂蛋白胆固醇之间的相互作用
DOI：
10.3389/fcvm.2022.863687
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发表时间：
2022
影响因子：
3.6
通讯作者：
Peng D
中科院分区：
文献类型：
--
作者：
Peng Y;Hu D;Luo Q;Peng D
虽然现有证据表明血清尿酸（SUA）水平升高与血脂异常之间存在联系，但SUA对血脂谱的潜在影响尚不清楚。实验和临床研究已经揭示了血清ANGPTL4水平高对脂质代谢产生有害影响的多种机制，但ANGPTL4在sua相关性血脂异常中的作用迄今尚未得到很好的研究。方法将80例受试者按全人群SUA中位数分为高SUA组（n = 40）和低SUA组（n = 40）。采用酶联免疫吸附法测定血清ANGPTL4水平。结果高SUA组不仅血清甘油三酯水平[1.03 (0.78,1.50)mmol/L比1.59 (1.18,2.37)mmol/L, p = 0.001]，而且血清富甘油三酯脂蛋白胆固醇（TRL-C）水平[0.38 (0.32,0.45)mmol/L比0.46 (0.34,0.54)mmol/L, p = 0.012]均显著升高。高SUA组血清ANGPTL4高于低SUA组[15.81 (11.88,20.82)ng/ml比22.13 (17.88,32.09)ng/ml, p = 0.000]。此外，在所有受试者中，TRL-C水平与SUA （r = 0.26, p = 0.023, n = 80）和ANGPTL4水平（r = 0.24, p = 0.036, n = 80）呈正相关。采用逐步多元回归分析调整潜在混杂因素，发现SUA是血清ANGPTL4的独立影响因素（p = 0.023）。同时，血清ANGPTL4是TRL-C水平的独立影响因素（p = 0.000）。而控制ANGPTL4水平后，SUA与TRL-C的相关性消失。结论血清尿酸与TRL-C呈正相关。ANGPTL4可能是SUA与相关TRL-C升高之间的相互作用。
Background Although the available evidence has indicated a link between elevated serum uric acid (SUA) level and dyslipidemia, the potential contribution of SUA on lipid profiles remains unclear. Experimental and clinical studies have revealed several mechanisms through which high serum angiopoietin-like protein 4 (ANGPTL4) level exerts deleterious effects on lipid metabolism, but the role of ANGPTL4 in SUA-associated dyslipidemia has not been well studied, so far. Methods A total of 80 subjects were classified into high SUA group (n = 40) and low SUA group (n = 40) by the median value of SUA in the whole study population. Serum ANGPTL4 levels were determined by enzyme-linked immunosorbent assays. Results In our study, we observed that not only serum triglyceride level [1.03 (0.78, 1.50) mmol/L vs. 1.59 (1.18, 2.37) mmol/L, p = 0.001] but also serum triglyceride-rich lipoprotein cholesterol (TRL-C) level [0.38 (0.32, 0.45) mmol/L vs. 0.46 (0.34, 0.54) mmol/L, p = 0.012] were significantly elevated in high SUA group. Additionally, serum ANGPTL4 in high SUA group was higher than in low SUA group [15.81 (11.88, 20.82) ng/ml vs. 22.13 (17.88, 32.09) ng/ml, p = 0.000]. Moreover, in all subjects, TRL-C levels were positively associated with SUA (r = 0.26, p = 0.023, n = 80) and ANGPTL4 levels (r = 0.24, p = 0.036, n = 80). Using stepwise multiple regression analysis to adjust for potential confounders, SUA was discovered to be an independent contributor to serum ANGPTL4 (p = 0.023). At the same time, serum ANGPTL4 was an independent contributor to the level of TRL-C (p = 0.000). However, the correlation between SUA and TRL-C disappeared after controlling for ANGPTL4 level. Conclusion Serum uric acid was positively correlated to TRL-C. ANGPTL4 may be an interplay between SUA and associated elevation of TRL-C.
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DOI：
10.1161/atvbaha.113.302802
发表时间：
2014-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
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影响因子：
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DOI：
10.1590/1806-9282.65.1.9
发表时间：
2019-01-01
期刊：
Revista da Associação Médica Brasileira
影响因子：
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作者：
Kocak, M. Zahid;Aktas, Gulali;Duman, Tuba
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Duman, Tuba
影响因子：
2.1
作者：
Cibickova, L.;Langova, K.;Karasek, D.
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