The Intrinsic Cardiac Nervous System and Its Role in Cardiac Pacemaking and Conduction.
The Intrinsic Cardiac Nervous System and Its Role in Cardiac Pacemaking and Conduction.
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DOI：
10.3390/jcdd7040054
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发表时间：
2020-11-24
影响因子：
2.4
通讯作者：
Brand T
中科院分区：
文献类型：
--
作者：
Fedele L;Brand T
心脏自主神经系统（CANS）对心脏活动起着重要的调节作用，其失调与心律失常等多种心脏疾病有关。CANS包括心脏的外在和内在神经支配。心内神经系统（ICNS）包括心内神经节和相互连接的神经元网络。心脏神经节参与心脏电生理的紧密调制，作为整合外源性神经支配和ICNS输入的局部枢纽。更好地了解ICNS对心脏传导系统的调节作用对于各种心律失常的靶向治疗至关重要。我们描述的胚胎发育，解剖学和生理学的ICNS。通过将心内神经元的地形与已知的生物物理和神经化学性质相关联，我们概述了它们在控制窦房结和房室结起搏器活动中的生理作用。最后，我们强调心脏疾病与ICNS的假定参与，并概述了开放的问题，需要解决，以更好地了解ICNS的生理和病理生理。
The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac activity with its dysregulation being involved in various heart diseases, such as cardiac arrhythmias. The CANS comprises the extrinsic and intrinsic innervation of the heart. The intrinsic cardiac nervous system (ICNS) includes the network of the intracardiac ganglia and interconnecting neurons. The cardiac ganglia contribute to the tight modulation of cardiac electrophysiology, working as a local hub integrating the inputs of the extrinsic innervation and the ICNS. A better understanding of the role of the ICNS for the modulation of the cardiac conduction system will be crucial for targeted therapies of various arrhythmias. We describe the embryonic development, anatomy, and physiology of the ICNS. By correlating the topography of the intracardiac neurons with what is known regarding their biophysical and neurochemical properties, we outline their physiological role in the control of pacemaker activity of the sinoatrial and atrioventricular nodes. We conclude by highlighting cardiac disorders with a putative involvement of the ICNS and outline open questions that need to be addressed in order to better understand the physiology and pathophysiology of the ICNS.
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影响因子：
4.2
作者：
Bumstock, Geoffrey
通讯作者：
Bumstock, Geoffrey
影响因子：
--
作者：
ATKINS, DL;ROSENTHAL, JK;MARVIN, WJ
通讯作者：
MARVIN, WJ
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影响因子：
4
作者：
Ashton JL;Burton RAB;Bub G;Smaill BH;Montgomery JM
通讯作者：
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影响因子：
5.8
作者：
Achanta, Sirisha;Gorky, Jonathan;Schwaber, James S.
通讯作者：
Schwaber, James S.
影响因子：
4.6
作者：
Bidaud, Isabelle;Chong, Antony Chung You;Mesirca, Pietro
通讯作者：
Mesirca, Pietro