A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters.
A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters.
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DOI：
10.1016/j.pbb.2011.09.005
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发表时间：
2012-01
影响因子：
3.6
通讯作者：
Cooper, Matthew A.
中科院分区：
文献类型：
--
作者：
Morrison, Kathleen E.;Cooper, Matthew A.
杏仁核基底外侧核（BLA）是大脑中调节压力事件（包括社交失败）后行为变化的关键区域。先前的研究表明，激活BLA中的5-羟色胺（5-HT） 1A受体可以减少条件性恐惧和焦虑样行为。本研究的目的是测试雄性叙利亚仓鼠（Mesocricetus auratus） BLA中的5-HT1A受体是否有助于条件失败。我们测试了在社交失败之前向BLA注射选择性5-HT1A受体激动剂肉肉素（400 ng， 800 ng或1200 ng， 200 nl生理盐水）是否会减少条件失败的获得，以及在测试之前注射类似的药物是否会减少条件失败的表达。我们还测试了在社交失败前向BLA注射选择性5-HT1A受体拮抗剂WAY-100635 （400 ng或1600 ng， 200 nl生理盐水）是否会增强条件失败的获得，以及在测试前注射类似的药物是否会增强条件失败的表达。我们发现，在BLA中注射肉毒素可以降低条件失败的获得和表达。然而，将WAY-100635注入BLA并没有改变条件失败的获得或表达。这些数据表明，BLA中5-HT1A受体的药理激活足以损害条件失败的获得和表达。我们的研究结果表明，激活BLA中5-HT1A受体的药物治疗能够减少应激诱导的行为变化的发展。
The basolateral nucleus of the amygdala (BLA) is a key brain region regulating behavioral changes following stressful events, including social defeat. Previous research has shown that activation of serotonin (5-HT) 1A receptors in the BLA reduces conditioned fear and anxiety-like behavior. The objective of this study was to test whether 5-HT1A receptors in the BLA contribute to conditioned defeat in male Syrian hamsters (Mesocricetus auratus). We tested whether injection of the selective 5-HT1A receptor agonist flesinoxan (400 ng, 800 ng, or 1200 ng in 200 nl saline) into the BLA prior to social defeat would reduce the acquisition of conditioned defeat, and whether a similar injection prior to testing would reduce the expression of conditioned defeat. We also tested whether injection of the selective 5-HT1A receptor antagonist WAY-100635 (400 ng or 1600 ng in 200 nl saline) into the BLA prior to social defeat would enhance the acquisition of conditioned defeat, and whether a similar injection prior to testing would enhance the expression of conditioned defeat. We found that injection of flesinoxan into the BLA decreased both the acquisition and expression of conditioned defeat. However, injection of WAY-100635 into the BLA did not alter the acquisition or expression of conditioned defeat. These data indicate that pharmacological activation of 5-HT1A receptors in the BLA is sufficient to impair the acquisition and expression of conditioned defeat. Our results suggest that pharmacological treatments that activate 5-HT1A receptors in the BLA are capable of reducing the development of stress-induced changes in behavior.
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影响因子：
5
作者：
Compaan, JC;Groenink, L;Olivier, B
通讯作者：
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中缝背核中 5-HT1A 自身受体的激活可减少社交失败的行为后果。
影响因子：
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作者：
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影响因子：
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作者：
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