Activation of 5-HT1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat.
Activation of 5-HT1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat.
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中缝背核中 5-HT1A 自身受体的激活可减少社交失败的行为后果。
DOI：
10.1016/j.psyneuen.2008.06.009
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发表时间：
2008-10
影响因子：
3.7
通讯作者：
Huhman, Kim L.
中科院分区：
文献类型：
--
作者：
Cooper, Matthew A.;McIntyre, Kathleen E.;Huhman, Kim L.
在动物模型中，血清素（5-HT）活性有助于应激诱导的行为改变。叙利亚仓鼠（Mesocricetus auratus）表现出压力引起的行为变化，在这种情况下，社会失败导致服从和防御行为增加，并完全失去对新的、无攻击性的对手的正常领土侵略。我们把这种由失败引起的对抗行为变化称为条件失败。在这项研究中，我们验证了5-羟色胺在中隔背核（DRN）中的活性有助于条件失败的获得和表达的假设。我们研究了在DRN中注射选择性5-HT1A激动剂肉肉素（200 ng, 400 ng, 800 ng， 200 nl生理盐水）是否会减少条件失败的获得和表达。此外，我们还研究了向DRN注射选择性5-HT1A拮抗剂WAY 100635 （400ng / 200nl生理盐水）是否会增强在次优社会失败经历后条件失败的获得和表达。我们发现，在暴露于15分钟的社交失败之前，向DRN注射肉毒素可以减少测试中显示的服从和防御行为的数量。我们还发现，在测试前向DRN注射肉毒素同样减少了顺从和防御行为。此外，我们发现WAY 100635在社交失败前或测试前注射时都能增强条件失败。这些数据支持了DRN中5-HT细胞的活性，受5-HT1A自受体调节，有助于条件失败的形成和表现的假设。此外，我们的研究结果表明，DRN投射区的5-HT释放增加了失败诱导的行为变化。
In animal models, serotonin (5-HT) activity contributes to stress-induced changes in behavior. Syrian hamsters (Mesocricetus auratus) exhibit a stress-induced change in behavior in which social defeat results in increased submissive and defensive behavior and a complete loss of normal territorial aggression directed toward a novel, non-aggressive opponent. We refer to this defeat-induced change in agonistic behavior as conditioned defeat. In this study we tested the hypothesis that 5-HT activity in the dorsal raphe nucleus (DRN) contributes to the acquisition and expression of conditioned defeat. We investigated whether injection of the selective 5-HT1A agonist flesinoxan (200 ng, 400 ng, 800 ng in 200 nl saline) into the DRN would reduce the acquisition and expression of conditioned defeat. Additionally, we investigated whether injection of the selective 5-HT1A antagonist WAY 100635 (400 ng in 200 nl saline) into the DRN would enhance the acquisition and expression of conditioned defeat following a sub-optimal social defeat experience. We found that injection of flesinoxan into the DRN before exposure to a 15-min social defeat reduced the amount of submissive and defensive behavior shown at testing. We also found that injection of flesinoxan into the DRN before testing similarly reduced submissive and defensive behavior. In addition, we found that WAY 100635 enhanced conditioned defeat when injected either before social defeat or before testing. These data support the hypothesis that the activity of 5-HT cells in the DRN, as regulated by 5-HT1A autoreceptors, contributes to the formation and display of conditioned defeat. Further, our results suggest that 5-HT release in DRN projection regions augments defeat-induced changes in behavior.
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DOI：
10.1017/s1461145701002632
发表时间：
2001-12-01
影响因子：
4.8
作者：
Bagdy, G;Graf, M;Kantor, S
通讯作者：
Kantor, S
影响因子：
10.6
作者：
Bergqvist, PBF;Bouchard, C;Blier, P
通讯作者：
Blier, P
影响因子：
3.4
作者：
Cooper, Matthew A.;Huhman, Kim L.
通讯作者：
Huhman, Kim L.
影响因子：
2.9
作者：
Amat, J;Matus-Amat, P;Maier, SF
通讯作者：
Maier, SF
影响因子：
3.3
作者：
Berton, O;Durand, M;Chaouloff, F
通讯作者：
Chaouloff, F