Cubic membranes: a legend beyond the Flatland* of cell membrane organization.

Cubic membranes: a legend beyond the Flatland* of cell membrane organization.
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立方膜:细胞膜组织的扁平地*之外的传奇。

DOI:
10.1083/jcb.200603055
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发表时间:
2006-06-19
影响因子:
7.8
通讯作者:
Deng, Yuru
Deng, Yuru
中科院分区:
生物学1区
文献类型:
--
作者:
Almsherqi, Zakaria A.;Kohlwein, Sepp D.;Deng, Yuru

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立方膜代表高度弯曲的三维纳米周期结构,其对应于数学上良好定义的三重周期最小表面。虽然它们已经在许多细胞类型和不同条件下观察到,特别是在应激,患病或病毒感染的细胞中,但关于生物系统中非层状立方结构的形成和功能的知识很少,迄今为止的研究仅限于描述性水平。我们表明,“有组织的平滑内质网”(OSER; Snapp,E.L.,R.S. Hegde,M. Francolini,F.隆巴多湾科隆博,E. Pedrazzini,N. Borgese,and J. Lippincott-Schwartz. 2003. J. Cell Biol.163:257-269),其响应于特定膜驻留蛋白水平的升高而形成,实际上是立方膜形态的两种亚型的二维表示。因此,控制OSER诱导,第一次,提供了一个有价值的工具,研究立方膜的形成和功能在分子水平上。
Cubic membranes represent highly curved, three-dimensional nanoperiodic structures that correspond to mathematically well defined triply periodic minimal surfaces. Although they have been observed in numerous cell types and under different conditions, particularly in stressed, diseased, or virally infected cells, knowledge about the formation and function of nonlamellar, cubic structures in biological systems is scarce, and research so far is restricted to the descriptive level. We show that the “organized smooth endoplasmic reticulum” (OSER; Snapp, E.L., R.S. Hegde, M. Francolini, F. Lombardo, S. Colombo, E. Pedrazzini, N. Borgese, and J. Lippincott-Schwartz. 2003. J. Cell Biol. 163:257–269), which is formed in response to elevated levels of specific membrane-resident proteins, is actually the two-dimensional representation of two subtypes of cubic membrane morphology. Controlled OSER induction may thus provide, for the first time, a valuable tool to study cubic membrane formation and function at the molecular level.
DOI: 10.1083/jcb.12.2.207
发表时间: 1962-02
影响因子: 7.8
作者:
LUZZATI, V;HUSSON, F
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DOI: 10.1007/s007090200017
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期刊: PROTOPLASMA
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发表时间: 2005-06-01
期刊: REDOX REPORT
影响因子: 3.8
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