Goodbye PAM: Phage λ's Red recombination system cripples PAMs and helps dodge CRISPR attacks.
Goodbye PAM: Phage λ's Red recombination system cripples PAMs and helps dodge CRISPR attacks.
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DOI:
10.1016/j.chom.2021.09.011
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发表时间:
2021-10-13
影响因子:
30.3
通讯作者:
Harshey, Rasika M.
中科院分区:
文献类型:
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作者:
Ho, Khang;Harshey, Rasika M.
Ever wondered how the phage λ Red recombination system resembles the Red Queen? provide an answer in this issue of Cell Host & Microbe. They show that Red debilitates PAM sequences by mutagenic repair of CRISPR-targeted DNA breaks in infecting λ, thus shaping the phage-CRISPR arms race.
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