Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation.
Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation.
复制标题
群体感应抑制剂在控制细菌生物膜形成中的调节机制和应用前景
DOI：
10.3389/fmicb.2020.589640
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发表时间：
2020
影响因子：
5.2
通讯作者：
Pan J
中科院分区：
文献类型：
--
作者：
Zhou L;Zhang Y;Ge Y;Zhu X;Pan J
生物膜是附着于表面并包封在胞外聚合物（EPS）基质中的微生物细胞的集合体。生物膜的形成是细菌耐药性的重要机制之一，它不仅导致人类和动物难以控制的细菌感染，而且使细菌成为食品加工，废水处理和金属加工等各个领域的主要问题。群体感应（Quorum sensing，QS）是一种细菌细胞间的信息传递过程，它依赖于细菌的种群密度，并由称为自诱导物（autoinducers，AI）的小的可扩散信号分子介导。细菌使用QS来调节多种功能，包括毒力和生物膜形成。因此，通过使用QS抑制剂（包括QS抑制剂（QSI）和群体淬灭（QQ）酶）来干扰QS以减少甚至完全抑制病原菌的生物膜形成似乎是控制细菌感染的有希望的方法。本文综述了QS调节生物膜形成的机制、QS抑制剂控制细菌生物膜形成的机制、新型QS抑制剂的发现策略以及QS抑制剂在多个领域的应用现状，以期为开发有效控制病原菌的药物提供参考。
A biofilm is an assemblage of microbial cells attached to a surface and encapsulated in an extracellular polymeric substance (EPS) matrix. The formation of a biofilm is one of the important mechanisms of bacterial resistance, which not only leads to hard-to-control bacterial infections in humans and animals but also enables bacteria to be a major problem in various fields, such as food processing, wastewater treatment and metalworking. Quorum sensing (QS) is a bacterial cell-to-cell communication process that depends on the bacterial population density and is mediated by small diffusible signaling molecules called autoinducers (AIs). Bacteria use QS to regulate diverse arrays of functions, including virulence and biofilm formation. Therefore, the interference with QS by using QS inhibiting agents, including QS inhibitors (QSIs) and quorum quenching (QQ) enzymes, to reduce or even completely repress the biofilm formation of pathogenic bacteria appears to be a promising approach to control bacterial infections. In this review, we summarize the mechanisms of QS-regulating biofilm formation and QS-inhibiting agents that control bacterial biofilm formation, strategies for the discovery of new QS inhibiting agents, and the current applications of QS-inhibiting agents in several fields to provide insight into the development of effective drugs to control pathogenic bacteria.
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影响因子：
3.6
作者：
Hammer, BK;Bassler, BL
通讯作者：
Bassler, BL
影响因子：
3.6
作者：
Allesen-Holm, M;Barken, KB;Tolker-Nielsen, T
通讯作者：
Tolker-Nielsen, T
影响因子：
64.5
作者：
ENGEBRECHT, J;NEALSON, K;SILVERMAN, M
通讯作者：
SILVERMAN, M
DOI：
10.1073/pnas.81.13.4154
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ENGEBRECHT, J;SILVERMAN, M
通讯作者：
SILVERMAN, M
影响因子：
4.9
作者：
D'Angelo, Francesca;Baldelli, Valerio;Rampioni, Giordano
通讯作者：
Rampioni, Giordano