Distribution and severity of weakness among patients with polymyositis, dermatomyositis and juvenile dermatomyositis.
Distribution and severity of weakness among patients with polymyositis, dermatomyositis and juvenile dermatomyositis.
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DOI：
10.1093/rheumatology/ken441
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发表时间：
2009-02
期刊：
影响因子：
5.5
通讯作者：
Rider, L. G.
中科院分区：
文献类型：
--
作者：
Harris-Love, M. O.;Shrader, J. A.;Koziol, D.;Pahlajani, N.;Jain, M.;Smith, M.;Cintas, H. L.;McGarvey, C. L.;James-Newton, L.;Pokrovnichka, A.;Moini, B.;Cabalar, I.;Lovell, D. J.;Wesley, R.;Plotz, P. H.;Miller, F. W.;Hicks, J. E.;Rider, L. G.
目的：通过对172例多发性肌炎(PM)、皮肌炎(DM)和幼年型皮肌炎(JDM)患者进行手动肌肉测试(MMT)，描述肌肉无力的分布和严重程度。次要目标包括在这一大群肌炎患者中确定个体肌肉群无力的特征，并确定无力与功能状态和肌炎特征的相关性。使用10分MMT对13个肌肉组的力量进行评估，并以总分、基于功能和解剖区域的亚分以及单个肌肉组的等级来表示。使用单变量和多变量分析评估患者特征和次要结果，如临床病程、肌肉酶、皮质类固醇剂量和功能状态与力量的关系。肌炎三个临床组的近端肌力较弱，PM最弱，DM居中，JDM最强(p≤0.0 5)。在所有三个临床组中，髋屈肌、髋伸肌、髋外展肌、颈部屈肌和肩外展肌是最弱的肌肉群。肌肉群受到对称性影响。轴向和近端肌肉损伤反映在我们队列中的肌炎患者共有的五块最弱的肌肉中。然而，在所有三个临床组中，都观察到了虚弱模式的差异。我们的研究结果表明，与DM相比，PM的近端无力更为严重。
To describe the distribution and severity of muscle weakness using manual muscle testing (MMT) in 172 patients with polymyositis (PM), dermatomyositis (DM) and juvenile dermatomyositis (JDM). The secondary objectives included characterizing individual muscle group weakness and determining associations of weakness with functional status and myositis characteristics in this large cohort of patients with myositis. Strength was assessed for 13 muscle groups using the 10-point MMT and expressed as a total score, subscores based on functional and anatomical regions, and grades for individual muscle groups. Patient characteristics and secondary outcomes such as clinical course, muscle enzymes, corticosteroid dosage, and functional status were evaluated for association with strength using univariate and multivariate analyses. A gradient of proximal weakness was seen, with PM weakest, DM intermediate and JDM strongest among the three myositis clinical groups (p ≤ 0.05). Hip flexors, hip extensors, hip abductors, neck flexors, and shoulder abductors were the muscle groups with the greatest weakness among all three clinical groups. Muscle groups were affected symmetrically. Axial and proximal muscle impairment was reflected in the five weakest muscles shared by our cohort of myositis patients. However, differences in the pattern of weakness were observed among all three clinical groups. Our findings suggest a greater severity of proximal weakness in PM in comparison to DM.
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影响因子：
3.4
作者：
Airio, A;Kautiainen, H;Hakala, M
通讯作者：
Hakala, M
影响因子：
--
作者：
BENBASSAT, J;GEFEL, D;ZLOTNICK, A
通讯作者：
ZLOTNICK, A
影响因子：
2.1
作者：
CASADEMONT, J;GRAU, JM;URBANOMARQUEZ, A
通讯作者：
URBANOMARQUEZ, A
DOI：
10.1016/j.berh.2004.02.009
发表时间：
2004-06-01
影响因子：
5.2
作者：
Christopher-Stine, L;Plotz, PH
通讯作者：
Plotz, PH
影响因子：
11
作者：
Mastaglia, FL;Phillips, BA;Zilko, PJ
通讯作者：
Zilko, PJ