Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: a population-based birth cohort study.
Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: a population-based birth cohort study.
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DOI：
10.1111/j.1469-7610.2012.02567.x
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Katusic SK
中科院分区：
文献类型：
--
作者：
Yoshimasu K;Barbaresi WJ;Colligan RC;Voigt RG;Killian JM;Weaver AL;Katusic SK
使用研究确定的ADHD事件病例和基于人群的对照，评估ADHD和共病精神障碍之间的关联。受试者包括出生于1976-1982年的所有儿童的出生队列，这些儿童在5岁后留在明尼苏达州的罗切斯特（n = 5718）。其中，我们确定了379例ADHD事件病例和758例年龄性别匹配的非ADHD对照，被动随访至19岁。所有的精神病诊断都被确定和提取，但只有那些由合格的医疗专业人员证实的才被纳入分析。对于每种精神疾病，使用Kaplan-Meier方法估计有和无ADHD受试者的累积发生率。采用校正性别、母亲年龄和受试者出生时教育程度的考克斯模型估计相应的风险比（HR）。通过估计比值比（OR），总结了ADHD与内化或外化障碍可能性之间的关联。ADHD与适应障碍（HR=3.88）、行为/对立违抗性障碍（HR=9.54）、心境障碍（HR=3.67）、焦虑障碍（HR=2.94）、抽动障碍（HR=6.53）、进食障碍（HR=5.68）、人格障碍（HR=5.80）和物质相关障碍（HR=4.03）的风险显著增加相关。当精神共病被归类在内化-外化维度上时，ADHD与共存的内化/外化（OR=10.6）或仅外化（OR=10.0）障碍密切相关。这项基于人群的研究证实，ADHD儿童患各种精神疾病的风险显著增加。除了治疗ADHD，临床医生还应该识别并提供适当的精神共病治疗。
To evaluate associations between ADHD and comorbid psychiatric disorders using research-identified incident cases of ADHD and population-based controls. Subjects included a birth cohort of all children born 1976–1982 remaining in Rochester, MN after age five (n = 5718). Among them we identified 379 ADHD incident cases and 758 age-sex matched non-ADHD controls, passively followed to age 19 years. All psychiatric diagnoses were identified and abstracted, but only those confirmed by qualified medical professionals were included in the analysis. For each psychiatric disorder, cumulative incidence rates for subjects with and without ADHD were estimated using the Kaplan-Meier method. Corresponding hazard ratios (HR) were estimated using Cox models adjusted for gender and mother’s age and education at the subject’s birth. The association between ADHD and the likelihood of having an internalizing or externalizing disorder was summarized by estimating odds ratios (OR). ADHD was associated with a significantly increased risk of adjustment disorders (HR=3.88), conduct/oppositional defiant disorder (HR=9.54), mood disorders (HR=3.67), anxiety disorders (HR=2.94), tic disorders (HR=6.53), eating disorders (HR=5.68), personality disorders (HR=5.80), and substance-related disorders (HR=4.03). When psychiatric comorbidities were classified on the internalization-externalization dimension, ADHD was strongly associated with coexisting internalizing/externalizing (OR=10.6), or externalizing-only (OR=10.0) disorders. This population-based study confirms that children with ADHD are at significantly increased risk for a wide range of psychiatric disorders. Besides treating the ADHD, clinicians should identify and provide appropriate treatment for psychiatric comorbidities.
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影响因子：
6.9
作者：
Biederman, J.;Petty, C. R.;Faraone, S. V.
通讯作者：
Faraone, S. V.
DOI：
10.1111/j.1469-7610.2007.01750.x
发表时间：
2007-08-01
影响因子：
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作者：
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作者：
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通讯作者：
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DOI：
10.1016/j.jaac.2009.09.007
发表时间：
2010-02-01
影响因子：
13.3
作者：
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通讯作者：
Szatmari, Peter
青少年共同出现的内在化和外部化疾病的结构和病因。
影响因子：
3.6
作者：
Cosgrove, Victoria E.;Rhee, Soo H.;Gelhorn, Heather L.;Boeldt, Debra;Corley, Robin C.;Ehringer, Marissa A.;Young, Susan E.;Hewitt, John K.
通讯作者：
Hewitt, John K.