Biodistribution of extracellular vesicles following administration into animals: A systematic review.
Biodistribution of extracellular vesicles following administration into animals: A systematic review.
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动物给药后细胞外囊泡的生物分布：系统综述。
DOI：
10.1002/jev2.12085
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发表时间：
2021-06
影响因子：
16
通讯作者：
Chamley LW
中科院分区：
文献类型：
--
作者：
Kang M;Jordan V;Blenkiron C;Chamley LW
近年来，人们的注意力已经转向检查EV在受体动物中的生物分布，以在体外和体内EV功能的知识之间建立桥梁。我们对文献进行了系统回顾，总结了电动汽车在动物体内的生物分布。小EV的生物分布存在时间依赖性变化，其在肝脏中最丰富。给药后第1小时，肝脏和肾脏中的检测达到峰值，而肺和脾脏中的分布在2-12小时达到峰值。大EV在肺部最丰富，在给药后第一个小时达到局部峰值，并在2-12小时之间减少。相比之下，随着肺中水平的降低，肝脏中的大EV定位增加。大型EV在肾脏的定位为中度至低度，而在脾脏的定位通常较低。无论EV的来源或大小或EV施用的受体物种如何，EV的生物分布主要分布于肝脏、肺、肾脏和脾脏。研究之间的方法存在极大的差异，我们建议应制定指南，以促进未来EV生物分布研究的标准化。
In recent years, attention has turned to examining the biodistribution of EVs in recipient animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a systematic review of the literature to summarize the biodistribution of EVs following administration into animals. There were time‐dependent changes in the biodistribution of small‐EVs which were most abundant in the liver. Detection peaked in the liver and kidney in the first hour after administration, while distribution to the lungs and spleen peaked between 2–12 h. Large‐EVs were most abundant in the lungs with localization peaking in the first hour following administration and decreased between 2–12 h. In contrast, large‐EV localization to the liver increased as the levels in the lungs decreased. There was moderate to low localization of large‐EVs to the kidneys while localization to the spleen was typically low. Regardless of the origin or size of the EVs or the recipient species into which the EVs were administered, the biodistribution of the EVs was largely to the liver, lungs, kidneys, and spleen. There was extreme variability in the methodology between studies and we recommend that guidelines should be developed to promote standardization where possible of future EV biodistribution studies.
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影响因子：
16
作者：
Crescitelli R;Lässer C;Szabó TG;Kittel A;Eldh M;Dianzani I;Buzás EI;Lötvall J
通讯作者：
Lötvall J
影响因子：
5.4
作者：
Grange C;Tapparo M;Bruno S;Chatterjee D;Quesenberry PJ;Tetta C;Camussi G
通讯作者：
Camussi G
影响因子：
4.6
作者：
Goh WJ;Zou S;Ong WY;Torta F;Alexandra AF;Schiffelers RM;Storm G;Wang JW;Czarny B;Pastorin G
通讯作者：
Pastorin G
影响因子：
5.6
作者：
Gangadaran P;Hong CM;Ahn BC
通讯作者：
Ahn BC
影响因子：
12.4
作者：
Faruqu, Farid N.;Wang, Julie Tzu-Wen;Al-Jamal, Khuloud T.
通讯作者：
Al-Jamal, Khuloud T.