The epidemiology of Mayaro virus in the Americas: A systematic review and key parameter estimates for outbreak modelling.
The epidemiology of Mayaro virus in the Americas: A systematic review and key parameter estimates for outbreak modelling.
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美洲马亚罗病毒的流行病学：爆发模型的系统性综述和关键参数估计。
DOI：
10.1371/journal.pntd.0009418
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发表时间：
2021-06
影响因子：
3.8
通讯作者：
Cucunubá ZM
中科院分区：
文献类型：
--
作者：
Caicedo EY;Charniga K;Rueda A;Dorigatti I;Mendez Y;Hamlet A;Carrera JP;Cucunubá ZM
马亚罗病毒（MAYV）是一种虫媒病毒，在中美洲和南美洲的热带森林中流行，特别是在亚马逊流域。近年来，人们越来越关注MAYV侵入城市地区并在整个地区造成流行病的能力。我们进行了系统的文献回顾，以确定MAYV的进化历史，其传播潜力和暴露于病毒的模式。我们分析了MAYV感染文献中的数据，以估计关键的流行病学参数，包括世代时间和基本繁殖数R 0。我们还估计了流行病和地方病环境中的感染力（FOI）。76篇出版物符合我们的纳入标准。在14个拉丁美洲国家报告了人、动物或病媒感染MAYV的证据。9个国家报告了经病毒分离或逆转录聚合酶链反应证实的人类急性感染证据。我们至少发现了五起MAYV疫情。基于人群的横断面研究的血清阳性率范围为21%至72%。MAYV的估计平均世代时间为15.2天（95%CrI：11.7-19.8），标准差为6.3天（95%CrI：4.2-9.5）。MAYV感染的人均风险（FOI）在每年0.01至0.05之间。亚马逊流域地区的平均R 0估计值介于2.1和2.9之间，亚马逊流域以外地区介于1.1和1.3之间。虽然在城市病媒中发现了MAYV，但还没有证据表明持续的城市传播。MAYV的地方性流行周期可以在城市内的森林地区建立，类似于黄热病病毒。每年，由蚊子传播的疾病在世界各地造成大量死亡和残疾。我们对马亚罗病毒（MAYV）进行了系统的文献综述，并估计了可用于改善未来疫情应对的关键流行病学参数。我们估计了一次历史暴发的世代时间和基本繁殖数。我们的研究结果表明，部队的感染MAYV在地方性环境是低的。我们没有发现MAYV大量城市传播的证据。然而，MAYV和黄热病病毒流行病学之间的相似性表明，MAYV可能出现在城市地区。在中美洲和南美洲以外的地方从未报告过MAYV的传播。我们的研究结果强调了继续监测美洲新兴虫媒病毒的必要性。
Mayaro virus (MAYV) is an arbovirus that is endemic to tropical forests in Central and South America, particularly within the Amazon basin. In recent years, concern has increased regarding MAYV’s ability to invade urban areas and cause epidemics across the region. We conducted a systematic literature review to characterise the evolutionary history of MAYV, its transmission potential, and exposure patterns to the virus. We analysed data from the literature on MAYV infection to produce estimates of key epidemiological parameters, including the generation time and the basic reproduction number, R0. We also estimated the force-of-infection (FOI) in epidemic and endemic settings. Seventy-six publications met our inclusion criteria. Evidence of MAYV infection in humans, animals, or vectors was reported in 14 Latin American countries. Nine countries reported evidence of acute infection in humans confirmed by viral isolation or reverse transcription-PCR (RT-PCR). We identified at least five MAYV outbreaks. Seroprevalence from population based cross-sectional studies ranged from 21% to 72%. The estimated mean generation time of MAYV was 15.2 days (95% CrI: 11.7–19.8) with a standard deviation of 6.3 days (95% CrI: 4.2–9.5). The per-capita risk of MAYV infection (FOI) ranged between 0.01 and 0.05 per year. The mean R0 estimates ranged between 2.1 and 2.9 in the Amazon basin areas and between 1.1 and 1.3 in the regions outside of the Amazon basin. Although MAYV has been identified in urban vectors, there is not yet evidence of sustained urban transmission. MAYV’s enzootic cycle could become established in forested areas within cities similar to yellow fever virus. Each year, diseases that are transmitted by mosquitoes cause substantial deaths and disability across the world. We performed a systematic literature review of Mayaro virus (MAYV) and estimated key epidemiological parameters that can be used to improve future outbreak response. We estimated the generation time and basic reproduction number for a historical outbreak. Our results suggest that the force-of-infection of MAYV in endemic settings is low. We did not find evidence of substantial urban transmission of MAYV. Nevertheless, similarities between MAYV and yellow fever virus epidemiology suggest that MAYV could emerge in urban areas. Local transmission of MAYV has never been reported outside of Central and South America. Our results highlight the need to continue monitoring emerging arboviruses in the Americas.
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影响因子：
3.2
作者：
Brady OJ;Johansson MA;Guerra CA;Bhatt S;Golding N;Pigott DM;Delatte H;Grech MG;Leisnham PT;Maciel-de-Freitas R;Styer LM;Smith DL;Scott TW;Gething PW;Hay SI
通讯作者：
Hay SI
影响因子：
11.8
作者：
Azevedo, Raimunda S. S.;Silva, Eliana V. P.;Vasconcelos, Pedro F. C.
通讯作者：
Vasconcelos, Pedro F. C.
影响因子：
3.8
作者：
Choi, Hyeree;Kudchodkar, Sagar B.;Muthumani, Kar
通讯作者：
Muthumani, Kar
影响因子：
2.7
作者：
da Silva Pessoa Vieira, Carla Julia;Ferreira da Silva, David Jose;de Morais Bronzoni, Roberta Vieira
通讯作者：
de Morais Bronzoni, Roberta Vieira
DOI：
10.3390/pathogens9090738
发表时间：
2020-09-08
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Diagne CT;Bengue M;Choumet V;Hamel R;Pompon J;Missé D
通讯作者：
Missé D