Effects of air pollution on the risk of congenital anomalies: a systematic review and meta-analysis.
Effects of air pollution on the risk of congenital anomalies: a systematic review and meta-analysis.
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DOI：
10.3390/ijerph110807642
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发表时间：
2014-07-31
影响因子：
--
通讯作者：
Deguen S
中科院分区：
文献类型：
--
作者：
Chen EK;Zmirou-Navier D;Padilla C;Deguen S
先天畸形是早产和新生儿死亡和发病的主要原因。我们通过结合各种空气污染物（SO2，NO2，PM10，PM2.5，CO和O3）和异常缺陷结果的风险估计，调查了先天性畸形与母亲在怀孕期间暴露于空气污染之间的关联。17篇文章被纳入系统综述，13项研究被纳入荟萃分析。根据暴露度量是连续的还是分类的，分别计算合并估计值。只有一个显著的组合是：NO2浓度与主动脉缩窄显著相关（OR = 1.20/10 ppb，95% CI，（1.02，1.41））。这一发现可能源于研究设计的强烈异质性。改进的暴露评估方法，特别是更准确的空间测量或建模，标准化的定义的情况下，更好地控制混杂因素，强烈建议在这一领域的未来先天性异常的研究。
Congenital anomalies are the main causes of preterm and neonatal mortality and morbidity. We investigated the association between congenital anomalies and mothers’ exposure to air pollution during pregnancy by combining risk estimates for a variety of air pollutants (SO2, NO2, PM10, PM2.5, CO and O3) and anomaly defect outcomes. Seventeen articles were included in the systematic review and thirteen studies were taken into account in the meta-analysis. Combined estimated were calculated separately according to whether the exposure metric was continuous or categorical. Only one significant combination was; NO2 concentrations were significantly associated with coarctation of the aorta (OR = 1.20 per 10 ppb, 95% CI, (1.02, 1.41)). This finding could stem from strong heterogeneity in study designs. Improved exposure assessment methods, in particular more accurate spatial measurements or modeling, standardized definition of cases and of better control of confounders are highly recommended for future congenital anomalies research in this area.
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