Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer.
Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer.
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DOI：
10.1038/sj.bjc.6603651
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发表时间：
2007-03-26
影响因子：
8.8
通讯作者：
Monden, M.
中科院分区：
文献类型：
--
作者：
Ngan, C. Y.;Yamamoto, H.;Seshimo, I.;Tsujino, T.;Man-i, M.;Ikeda, J-I;Konishi, K.;Takemasa, I.;Ikeda, M.;Sekimoto, M.;Matsuura, N.;Monden, M.
最近的研究已经确定了波形蛋白，III型中间丝，在肿瘤中差异表达的基因更具侵袭性的功能，表明波形蛋白和肿瘤进展之间的关联。本研究的目的是调查波形蛋白在结肠癌组织中的表达是否具有临床相关性。我们在142例结直肠癌（CRC）样本中进行了免疫染色，并使用计算机辅助图像分析定量波形蛋白表达量。结直肠癌肿瘤间质中波形蛋白的表达与较短的生存期相关。波形蛋白高表达组的总生存率为71.2%，而低表达组为90.4%（P=0.002），而高表达组的无病生存率为62.7%，而低表达组为86.7%（P=0.001）。此外，波形蛋白对疾病复发的预后能力在II期和III期CRC中均保持不变。多因素分析表明，波形蛋白是一个更好的疾病复发的预后指标（风险比=3.5）比广泛使用的淋巴结状态（风险比=2.2）。波形蛋白在肿瘤间质中的表达可能反映了肿瘤更高的恶性潜能，并且可能是CRC患者疾病复发的有用预测标志物。
Recent studies have identified vimentin, a type III intermediate filament, among genes differentially expressed in tumours with more invasive features, suggesting an association between vimentin and tumour progression. The aim of this study, was to investigate whether vimentin expression in colon cancer tissue is of clinical relevance. We performed immunostaining in 142 colorectal cancer (CRC) samples and quantified the amount of vimentin expression using computer-assisted image analysis. Vimentin expression in the tumour stroma of CRC was associated with shorter survival. Overall survival in the high vimentin expression group was 71.2% compared with 90.4% in the low-expression group (P=0.002), whereas disease-free survival for the high-expression group was 62.7% compared with 86.7% for the low-expression group (P=0.001). Furthermore, the prognostic power of vimentin for disease recurrence was maintained in both stage II and III CRC. Multivariate analysis suggested that vimentin was a better prognostic indicator for disease recurrence (risk ratio=3.5) than the widely used lymph node status (risk ratio=2.2). Vimentin expression in the tumour stroma may reflect a higher malignant potential of the tumour and may be a useful predictive marker for disease recurrence in CRC patients.
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影响因子：
21.3
作者：
Mor-Vaknin, N;Punturieri, A;Markovitz, DM
通讯作者：
Markovitz, DM
影响因子：
8.8
作者：
CONFORTI, G;CODEGONI, AM;BROGGINI, M
通讯作者：
BROGGINI, M
影响因子：
2.8
作者：
Lang, SH;Hyde, C;Maitland, NJ
通讯作者：
Maitland, NJ
影响因子：
2.7
作者：
Brabletz, T;Hlubek, F;Kirchner, T
通讯作者：
Kirchner, T
影响因子：
4
作者：
Helfand, BT;Chang, L;Goldman, RD
通讯作者：
Goldman, RD