Nerve growth factor decreases in sympathetic and sensory nerves of rats with chronic heart failure.
Nerve growth factor decreases in sympathetic and sensory nerves of rats with chronic heart failure.
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DOI：
10.1007/s11064-014-1348-5
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发表时间：
2014-08
影响因子：
4.4
通讯作者：
Li, Jianhua
中科院分区：
文献类型：
--
作者：
Xing, Jihong;Lu, Jian;Li, Jianhua
神经生长因子（NGF）在交感神经和感觉神经的维持和存活中起着关键作用。此外，神经生长因子可以调节受体的表达和神经元的活动，在交感神经元和感觉神经元。在心力衰竭（HF）患者和动物中观察到NGF调节的异常。然而，慢性HF对交感神经和感觉神经内的NGF水平的影响尚不清楚。因此，ELISA方法用于评估对照大鼠和心肌梗死诱导的慢性HF大鼠的星状神经节（SG）和背根神经节（DRG）神经元中的NGF水平。首次发现冠状动脉结扎后6-20周，SG和DRG神经元中NGF含量显著降低（P < 0.05）。此外，NGF水平与左心室功能密切相关。总之，慢性HF损害交感神经和感觉神经中NGF的表达。鉴于感觉传入神经通过反射机制参与对躯体刺激（即运动期间的肌肉活动）的交感神经反应，我们的数据表明，NGF可能是慢性HF中观察到的肌肉反射介导的异常交感神经反应的发展的原因。
Nerve growth factor (NGF) plays a critical role in the maintenance and survival of both sympathetic and sensory nerves. Also, NGF can regulate receptor expression and neuronal activity in the sympathetic and sensory neurons. Abnormalities in NGF regulation are observed in patients and animals with heart failure (HF). Nevertheless, the effects of chronic HF on the levels of NGF within the sympathetic and sensory nerves are not known. Thus, the ELISA method was used to assess the levels of NGF in the stellate ganglion (SG) and dorsal root ganglion (DRG) neurons of control rats and rats with chronic HF induced by myocardial infarction. Our data show for the first time that the levels of NGF were significantly decreased (P < 0.05) in the SG and DRG neurons 6–20 weeks after ligation of the coronary artery. In addition, a close relation was observed between the NGF levels and the left ventricular function. In conclusion, chronic HF impairs the expression of NGF in the sympathetic and sensory nerves. Given that sensory afferent nerves are engaged in the sympathetic nervous responses to somatic stimulation (i.e. muscle activity during exercise) via a reflex mechanism, our data indicate that NGF is likely responsible for the development of muscle reflex-mediated abnormal sympathetic responsiveness observed in chronic HF.
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影响因子：
20.1
作者：
Cao, JM;Chen, LS;Chen, PS
通讯作者：
Chen, PS
DOI：
10.1152/ajpheart.00394.2004
发表时间：
2004-12-01
影响因子：
4.8
作者：
Momen, A;Bower, D;Sinoway, LI
通讯作者：
Sinoway, LI
影响因子：
10.8
作者：
KAUFMAN, MP;WALDROP, TG;MITCHELL, JH
通讯作者：
MITCHELL, JH
影响因子：
8.3
作者：
Kreusser, MM;Haass, M;Backs, J
通讯作者：
Backs, J
影响因子：
20.1
作者：
KAUFMAN, MP;IWAMOTO, GA;MITCHELL, JH
通讯作者：
MITCHELL, JH