Systemic cytokine levels and subsequent risk of gastric cancer in Chinese Women.
Systemic cytokine levels and subsequent risk of gastric cancer in Chinese Women.
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DOI：
10.1111/j.1349-7006.2011.02033.x
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发表时间：
2011-10
期刊：
影响因子：
5.7
通讯作者：
Chow WH
中科院分区：
文献类型：
--
作者：
Wong HL;Rabkin CS;Shu XO;Pfeiffer RM;Cai Q;Ji BT;Yang G;Li HL;Rothman N;Gao YT;Zheng W;Chow WH
已知宿主细胞因子网络的控制影响胃癌的易感性；胃癌发生过程中的特异性炎症反应尚不清楚。在《上海妇女健康研究》中，我们前瞻性地研究了血浆白介素1β、白介素6、白介素8和肿瘤坏死因子α水平与胃癌风险的关系。根据年龄、绝经状态和样本采集参数，将两个对照与每个病例相匹配。通过条件Logistic回归的优势比(ORs)和95%可信区间(%Cis)估计胃癌风险与细胞因子水平的相关性，并对教育因素进行调整。在中位数4年(范围0.1-8)的随访期内，141名女性患上了胃癌，并与282名无癌研究参与者进行了配对。血浆IL-6水平升高与患胃癌的风险增加相关(Ρ趋势=0.04)。与IL-6水平最低的三分位数(<；1.8pg/mL)相比，IL-6水平最高的三分位数(>；4pg/m l)的妇女的风险增加了70%(OR=1.7，95%CI，1.0，3.0)。在随访4年后，IL6的相关性更强(OR=2.6，95%CI，1.0，6.7，与最低三分位数相比)，而那些在1-4年内确诊的患者的OR为1.4(0.7，2.9)。未观察到与其他被检查的促炎细胞因子IL-1β、IL-8和肿瘤坏死因子α之间的相关性。系统性血浆IL-6水平可能提示胃癌的长期风险。这一新发现等待着未来对顺序血浆采集的研究证实。
The control of the host cytokine network is known to influence gastric cancer susceptibility; the specific inflammatory responses in gastric carcinogenesis remain unclear. We prospectively examined the relationships of plasma levels of interleukin (IL)-1β, IL6, IL8 and tumor necrosis factor (TNF)-α to gastric cancer risk within The Shanghai Women’s Health Study. Two controls were matched to each case by age, menopausal status and sample collection parameters. The associations of gastric cancer risk and tertile of cytokine levels were estimated by odds ratios (ORs) and 95 per cent confidence intervals (% CIs) from conditional logistic regression, adjusting for education. During a median follow-up period of 4 years (range: 0.1–8), 141 women developed gastric cancer and were matched to 282 cancer-free study participants. Elevated levels of plasma IL6 were associated with an increased risk of gastric cancer (Ρtrend=0.04). Risk increased 70% (OR=1.7, 95% CI, 1.0, 3.0) for women in the highest tertile (> 4 pg/mL) of IL-6 compared to those in the lowest tertile (<1.8 pg/mL). The association with IL6 was stronger after 4 years of follow-up (OR=2.6, 95% CI, 1.0, 6.7 for highest vs. lowest tertile) compared to an OR of 1.4 (0.7, 2.9) for those diagnosed within 1–4 years of follow-up. No associations were observed with the other examined pro-inflammatory cytokines, IL1β, IL8 and TNFα. Systemic plasma IL6 levels may inform long-term gastric cancer risk. This novel finding awaits confirmation in future studies with sequential plasma collection.
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影响因子：
24.5
作者：
Graham, DY;Opekun, AR;Monath, TP
通讯作者：
Monath, TP
影响因子：
2.1
作者：
Shariat, SF;Andrews, B;Slawin, KM
通讯作者：
Slawin, KM
影响因子：
2.4
作者：
Mahajan, Rajeev;El-Omar, Emad M.;Hou, Lifang
通讯作者：
Hou, Lifang
DOI：
10.1007/s10120-005-0315-x
发表时间：
2005-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Ashizawa, Tatsuto;Okada, Ryosuke;Aoki, Tatsuya
通讯作者：
Aoki, Tatsuya
影响因子：
29.4
作者：
Cover TL;Blaser MJ
通讯作者：
Blaser MJ