Helicobacter pylori in health and disease.

Helicobacter pylori in health and disease.
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DOI:
10.1053/j.gastro.2009.01.073
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发表时间:
2009-05
期刊:
影响因子:
29.4
通讯作者:
Blaser MJ
Blaser MJ
中科院分区:
医学1区
文献类型:
--
作者:
Cover TL;Blaser MJ

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幽门螺杆菌非常适合在人类胃中定植,并且存在于大约一半的人口中。当存在时,幽门螺杆菌通常是数量上占优势的胃微生物。幽门螺杆菌通常不会引起任何副作用,但与非贲门胃腺癌、胃淋巴瘤和消化性溃疡的风险增加有关。最近据报道,与幽门螺杆菌阳性的人相比,缺乏幽门螺杆菌的个体更容易发生食道疾病和儿童期哮喘等疾病。在这篇综述中,我们讨论了幽门螺杆菌在人类胃中定植的生物学因素、幽门螺杆菌增加消化性溃疡病和非贲门胃腺癌风险的机制,以及幽门螺杆菌可能给人类带来的潜在益处。
Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H. pylori is usually the numerically dominant gastric microorganism. H. pylori typically does not cause any adverse effects, but is associated with an increased risk of non-cardia gastric adenocarcinoma, gastric lymphoma and peptic ulcer. Disorders such as esophageal diseases and childhood-onset asthma have been recently reported to occur more frequently in individuals who lack H. pylori, compared with H. pylori-positive persons. In this review, we discuss biologic factors that allow H. pylori to colonize the human stomach, mechanisms by which H. pylori increases the risk for peptic ulcer disease and non-cardia gastric adenocarcinoma, and potential benefits that H. pylori might confer to humans.
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发表时间: 2001-09-01
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