Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes.
Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes.
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DOI：
10.1038/s41598-020-80266-5
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发表时间：
2021-01-12
影响因子：
4.6
通讯作者：
Kim MG
中科院分区：
文献类型：
--
作者：
Gwon JG;Choi J;Jung CW;Lee CH;Oh SW;Jo SK;Cho WY;Park JB;Huh KH;Ro H;Han S;Cho JH;Lee S;Yang J;Kim MG
最近，腰臀比（WHR）已被报道是一个更好的指标预测心血管疾病的结果比体重指数（BMI）。目的探讨肾移植（KT）受者移植前后腰臀比（WHR）和体重指数（BMI）变化对新发心血管疾病（CVD）的影响。从多中心观察性队列（KNOW-KT）中共入组了572例患者。分别于术前、术后1年及末次随访时测量腰臀比（WHR）、体重指数（BMI），分析其变化及其对心血管事件的影响。中位随访时间为32.73 ± 15.26个月，572例患者中有31例新发CVD。高龄、糖尿病和腰臀比较术前或随访前增加是预测新发心血管疾病的独立因素。然而，KT前的基线BMI、WHR不能预测CVD的发生。新的代谢负荷，表现为KT患者WHR的增加，对新发CVD的发展有重要影响。预防KT后代谢负担的策略可能会改善心血管结局和患者的生存率。
Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney transplantation (KT). A total of 572 patients were enrolled from a multicenter observational cohort (KNOW-KT). Measurement of WHR and BMI was done at pre-KT, first and last visit year after KT, and the changes of these parameters and their effect on the incident CVD were analyzed. During the median follow up period of 32.73 ± 15.26 months, the new onset CVD developed in 31 out of 572 patients. The older age, diabetes mellitus and increase of WHR from pre KT or previous follow up year were found to be independent factors predicting the new onset CVD in these patients. However, baseline BMI, WHR prior to KT did not predict the incident CVD. The new metabolic burden, presented as increase of WHR in KT patients has a critical impact on the development of new onset CVD. Strategies to prevent the metabolic burden after KT might improve cardiovascular outcomes and patient’s survival.
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影响因子：
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