A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection.
A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection.
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DOI：
10.1155/2013/197163
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发表时间：
2013
影响因子：
0.9
通讯作者：
Taniguchi K
中科院分区：
文献类型：
--
作者：
Matsuoka T;Yodoshi T;Sugai M;Hiyane M;Matsuoka T;Akeda H;Ohfu M;Komoto S;Taniguchi K
我们报告一个由轮状病毒感染引起的急性肠胃炎合并可逆性脾损害的轻度脑病病例。患者（男，4岁零3个月）因腹泻和无热惊厥入院。头部MRI显示DWI上胼胝体压部高信号，ADC图上低信号。从镇静中醒来后，患者的意识障碍改善。入院后第5天，患者出院，情况良好。入院后第2天脑电图正常。在入院第8天，头部MRI显示压层病变已经消失。RV抗原阳性粪便表明RV引起了MERS。该RV基因型被认为是G5 P [6];它可能通过将猪RV替换为人RV基因片段作为菌株重配传播给人类。这种极其罕见的基因型首先在日本被发现，现有的疫苗没有覆盖;这是第一个从脑病患者中分离出来的样本。很少有报道调查RV基因型在脑病，我们认为，这种情况下是有价值的研究基因型和临床症状之间的关系。
We report a case of mild encephalopathy with a reversible splenial lesion (MERS) associated with acute gastroenteritis caused by rotavirus (RV) infection. The patient (male, 4 years and 3 months old) was admitted to our hospital for diarrhea and afebrile seizures. Head MRI revealed a hyperintense signal in the splenium of the corpus callosum on DWI and a hypointense signal on the ADC-map. After awakening from sedation, the patient's disturbance of consciousness improved. On day 5 after admission of the illness, the patient was discharged from the hospital in a good condition. Electroencephalography on day 2 after admission was normal. On day 8 of admission, head MRI revealed that the splenial lesion had disappeared. RV antigen-positive stools suggested that RV had caused MERS. This RV genotype was considered to be G5P[6]; it may have spread to humans as a strain reassortment through substitution of porcine RV into human RV gene segments. This extremely rare genotype was detected first in Japan and is not covered by existing vaccines; this is the first sample isolated from encephalopathy patients. Few reports have investigated RV genotypes in encephalopathy; we believe that this case is valuable for studying the relationship between genotypes and clinical symptoms.
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