A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology.
A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology.
复制标题
内皮祖细胞对骨生物学作用的见解综述
DOI：
10.3389/fcell.2022.878697
复制
发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
除了其重要的运输功能外，骨骼系统还参与调节血管的复杂生物活动。内皮祖细胞（Endothelial progenitor cells，EPCs）作为内皮细胞（endothelial cells，ECs）的干细胞，在分化前具有良好的增殖能力和血管生成能力。通过与多种细胞共培养，它们表现出协同作用，以更有效地促进骨再生和血管化。内皮祖细胞通过分泌多种生长因子、调节细胞功能和促进骨再生，显示出治疗各种骨疾病的显著治疗潜力。本文综述了EPCs的定义、特性及其与间充质干细胞、内皮细胞、平滑肌细胞和免疫细胞在骨再生、血管化和免疫中的相互作用，总结了EPCs的作用机制及其对骨生物学的贡献。此外，我们还总结了它们在治疗各种骨疾病中的作用和潜在机制，可能预示着它们的临床应用。
In addition to its important transport functions, the skeletal system is involved in complex biological activities for the regulation of blood vessels. Endothelial progenitor cells (EPCs), as stem cells of endothelial cells (ECs), possess an effective proliferative capacity and a powerful angiogenic capacity prior to their differentiation. They demonstrate synergistic effects to promote bone regeneration and vascularization more effectively by co-culturing with multiple cells. EPCs demonstrate a significant therapeutic potential for the treatment of various bone diseases by secreting a combination of growth factors, regulating cellular functions, and promoting bone regeneration. In this review, we retrospect the definition and properties of EPCs, their interaction with mesenchymal stem cells, ECs, smooth muscle cells, and immune cells in bone regeneration, vascularization, and immunity, summarizing their mechanism of action and contribution to bone biology. Additionally, we generalized their role and potential mechanisms in the treatment of various bone diseases, possibly indicating their clinical application.
登录
查看更多内容
CGS21680通过调节内皮祖细胞的促炎活性促进组织工程血管通畅。
影响因子：
4.9
作者：
Chen, Wen;Xiao, Li;Zhu, Chuhong
通讯作者：
Zhu, Chuhong
DOI：
10.1002/stem.2810
发表时间：
2018-06
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Chambers SEJ;O'Neill CL;Guduric-Fuchs J;McLoughlin KJ;Liew A;Egan AM;O'Brien T;Stitt AW;Medina RJ
通讯作者：
Medina RJ
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
3.7
作者：
Aggarwal R;Lu J;Kanji S;Joseph M;Das M;Noble GJ;McMichael BK;Agarwal S;Hart RT;Sun Z;Lee BS;Rosol TJ;Jackson R;Mao HQ;Pompili VJ;Das H
通讯作者：
Das H
影响因子：
20.1
作者：
Foubert, Philippe;Matrone, Gianfranco;Tobelem, Gerard
通讯作者：
Tobelem, Gerard