Diverse and potentially manipulative signalling with ascarosides in the model nematode C. elegans.
Diverse and potentially manipulative signalling with ascarosides in the model nematode C. elegans.
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DOI：
10.1186/1471-2148-14-46
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发表时间：
2014-03-11
影响因子：
3.4
通讯作者：
Viney M
中科院分区：
文献类型：
--
作者：
Diaz SA;Brunet V;Lloyd-Jones GC;Spinner W;Wharam B;Viney M
动物利用环境信息来做出发展决策，以最大化它们的健康。线虫秀丽线虫通过测量其环境来决定是停止幼虫的发育，还是继续生长和繁殖。蠕虫被认为使用蛔虫苷作为种群密度的信号，这种信号被认为是整个物种的诚实信号。我们比较了最近野生线虫品系在不同食物环境中提供相同的蛔虫苷信号时的达尔幼虫捕获率。我们发现，迄今为止典型的达尔幼虫反应在这些品系中并不成立。根据食物环境的不同，蛔虫苷分子既可以促进也可以抑制达尔幼虫的形成。此外，这些最近野生的线虫株系还产生蛔虫苷混合物，引起广泛不同的达尔幼虫形成反应。我们进一步发现，这些线条在它们释放的蛔虫苷分子的数量和比例上是不同的。达尔幼虫的一些形成反应与不诚实的信号一致。总之，这些结果表明，达尔幼虫的形成是一种诚实地发出信号的线虫广泛影响的想法是站不住脚的。相反，结果表明，基于蛔虫苷的信令是一个公共广播信息系统，但对该信息的正确解释取决于蠕虫的上下文，并且是一个对不诚实信令开放的系统。
Animals use environmental information to make developmental decisions to maximise their fitness. The nematode Caenorhabditis elegans measures its environment to decide between arresting development as dauer larvae or continuing to grow and reproduce. Worms are thought to use ascarosides as signals of population density and this signalling is thought to be a species-wide honest signal. We compared recently wild C. elegans lines’ dauer larva arrest when presented with the same ascaroside signals and in different food environments. We find that the hitherto canonical dauer larva response does not hold among these lines. Ascaroside molecules can, depending on the food environment, both promote and repress dauer larva formation. Further, these recently wild C. elegans lines also produce ascaroside mixtures that induce a wide diversity of dauer larva formation responses. We further find that the lines differ in the quantity and ratios of ascaroside molecules that they release. Some of the dauer larva formation responses are consistent with dishonest signalling. Together, the results suggest that the idea that dauer larva formation is an honestly-signalled C. elegans-wide effect does not hold. Rather, the results suggest that ascaroside-based signalling is a public broadcast information system, but where the correct interpretation of that information depends on the worms’ context, and is a system open to dishonest signalling.
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比较代谢组学揭示了丙烷剂的生物发生，这是秀丽隐杆线虫中小分子信号的模块化库。
影响因子：
15
作者：
von Reuss, Stephan H.;Bose, Neelanjan;Srinivasan, Jagan;Yim, Joshua J.;Judkins, Joshua C.;Sternberg, Paul W.;Schroeder, Frank C.
通讯作者：
Schroeder, Frank C.
影响因子：
3.4
作者：
Harvey SC;Shorto A;Viney ME
通讯作者：
Viney ME
影响因子：
8.8
作者：
Geiselhardt, Sven;Otte, Tobias;Hilker, Monika
通讯作者：
Hilker, Monika
影响因子：
9.2
作者：
Choe, Andrea;von Reuss, Stephan H.;Kogan, Dima;Gasser, Robin B.;Platzer, Edward G.;Schroeder, Frank C.;Sternberg, Paul W.
通讯作者：
Sternberg, Paul W.
DOI：
10.1895/wormbook.1.155.1
发表时间：
2013-01-18
期刊：
WormBook : the online review of C. elegans biology
影响因子：
--
作者：
Ludewig AH;Schroeder FC
通讯作者：
Schroeder FC