Quantitative genetic analysis of life-history traits of Caenorhabditis elegans in stressful environments.
Quantitative genetic analysis of life-history traits of Caenorhabditis elegans in stressful environments.
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DOI：
10.1186/1471-2148-8-15
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发表时间：
2008-01-22
影响因子：
3.4
通讯作者：
Viney ME
中科院分区：
文献类型：
--
作者：
Harvey SC;Shorto A;Viney ME
生物体生活在多变的环境中。对于不同环境的生活史特征，当表型与环境条件适当匹配时，适应性将最大化。对于自由生活的秀丽隐杆线虫（Caenorhabditis elegans），我们研究了两个主要的生活史特征，(i)环境抗性幼虫的发育和（ii）繁殖，如何应对环境压力（高种群密度和低食物可用性），以及这些特征如何在不同品系之间变化以及这种变化的遗传基础。研究发现，不同系秀丽隐杆线虫幼虫发育的表型可塑性存在差异，即在相同的环境变化条件下发育成幼虫的可能性存在差异。在环境压力条件下，终生繁殖力和繁殖率的变化也存在差异。这些性状是相关的，因此，对大鼠幼虫发育具有高度可塑性的品系在受到胁迫时也能保持较高的种群增长率。我们在两条染色体上发现了控制幼虫发育和种群大小表型的数量性状位点（QTL）。在第2染色体上，影响幼虫发育和种群大小表型的qtl是密切相关的，但在遗传上是可分离的。这个控制幼虫发育的第II染色体QTL不包含任何先前发现的控制幼虫发育的位点。这个染色体II区域包含许多预测的7-跨膜受体。这些蛋白通常参与信息转导，这显然与控制幼虫的发育有关。秀丽隐杆线虫在环境胁迫下改变幼虫发育和成虫繁殖策略。表现型和基因型数据表明，这两种主要的生活史特征是对环境压力的协调反应，它们至少在一定程度上是由相同的基因组区域控制的。
Organisms live in environments that vary. For life-history traits that vary across environments, fitness will be maximised when the phenotype is appropriately matched to the environmental conditions. For the free-living nematode Caenorhabditis elegans, we have investigated how two major life-history traits, (i) the development of environmentally resistant dauer larvae and (ii) reproduction, respond to environmental stress (high population density and low food availability), and how these traits vary between lines and the genetic basis of this variation. We found that lines of C. elegans vary in their phenotypic plasticity of dauer larva development, i.e. there is variation in the likelihood of developing into a dauer larva for the same environmental change. There was also variation in how lifetime fecundity and the rate of reproduction changed under conditions of environmental stress. These traits were related, such that lines that are highly plastic for dauer larva development also maintain a high population growth rate when stressed. We identified quantitative trait loci (QTL) on two chromosomes that control the dauer larva development and population size phenotypes. The QTLs affecting the dauer larva development and population size phenotypes on chromosome II are closely linked, but are genetically separable. This chromosome II QTL controlling dauer larva development does not encompass any loci previously identified to control dauer larva development. This chromosome II region contains many predicted 7-transmembrane receptors. Such proteins are often involved in information transduction, which is clearly relevant to the control of dauer larva development. C. elegans alters both its larval development and adult reproductive strategy in response to environmental stress. Together the phenotypic and genotypic data suggest that these two major life-history traits are co-ordinated responses to environmental stress and that they are, at least in part, controlled by the same genomic regions.
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影响因子：
11.4
作者：
Mackay, Trudy F. C.;Anholt, Robert R. H.
通讯作者：
Anholt, Robert R. H.
影响因子：
56.9
作者：
GOLDEN, JW;RIDDLE, DL
通讯作者：
RIDDLE, DL
在秀丽隐杆线虫中，基因基因组学对基因表达可塑性的映射决定因素。
影响因子：
4.5
作者：
Li, Yang;Alvarez, Olga Alda;Gutteling, Evert W.;Tijsterman, Marcel;Fu, Jingyuan;Riksen, Joost A. G.;Hazendonk, Esther;Prins, Pjotr;Plasterk, Ronald H. A.;Jansen, Ritsert C.;Breitling, Rainer;Kammenga, Jan E.
通讯作者：
Kammenga, Jan E.
影响因子：
64.8
作者：
Jeong, PY;Jung, M;Paik, YK
通讯作者：
Paik, YK
DOI：
10.1111/j.1469-1809.1943.tb02321.x
发表时间：
1943-01-01
期刊：
ANNALS OF EUGENICS
影响因子：
--
作者：
Kosambi, DD
通讯作者：
Kosambi, DD