Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies.
Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies.
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DOI：
10.1002/jeab.744
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发表时间：
2022-05
影响因子：
2.7
通讯作者：
Stoops, William W.
中科院分区：
文献类型：
--
作者：
Regnier, Sean D.;Lile, Joshua A.;Rush, Craig R.;Stoops, William W.
可卡因的使用是一个挥之不去的公共卫生问题。为了告知干预和预防工作，至关重要的是发展对可卡因强化作用的临床神经药理学的理解。本综述的目的是评价和综合评估可卡因自我给药药理学操作的人类实验室研究。对41项经同行评审的人类可卡因自我给药研究进行了评估，其中参与者接受了预处理药物。回顾了所有药物的药理作用和治疗方案。增加细胞外多巴胺的药物往往对可卡因的自我给药有最一致的效果。非多巴胺能药物影响可卡因强化的能力可能与它们对多巴胺的下游作用有关，尽管很难得出结论，因为药理学选择性化合物尚未广泛用于人体试验。由于丁丙诺啡是唯一在急性和慢性给药方案下进行评估的前处理药物，因此，急性和慢性药物治疗对人类可卡因自我给药的不同影响的能力尚未确定。未来的研究需要直接比较急慢性药物治疗和/或比较不同作用机制的药物，以对可卡因强化的临床神经药理学做出更结论性的确定。
Cocaine use is an unrelenting public health concern. To inform intervention and prevention efforts, it is crucial to develop an understanding of the clinical neuropharmacology of the reinforcing effects of cocaine. The purpose of this review is to evaluate and synthesize human laboratory studies that assess pharmacological manipulations of cocaine self-administration. Forty-one peer-reviewed, human cocaine self-administration studies in which participants received a pretreatment drug were assessed. The pharmacological action and treatment regimen for all drugs reviewed were considered. Drugs that increase extracellular dopamine tend to have the most consistent effects on cocaine self-administration. The ability of nondopaminergic drugs to impact cocaine reinforcement might be related to their downstream effects on dopamine, though it is difficult to draw conclusions because pharmacologically selective compounds are not widely available for human testing. The ability of acute versus chronic drug treatment to differentially affect human cocaine self-administration was not determined because buprenorphine was the only pretreatment drug that was assessed under both acute and chronic dosing regimens. Future research directly comparing acute and chronic drug treatment and/or comparing drugs with different mechanisms of action, is needed to make more conclusive determinations about the clinical neuropharmacology of cocaine reinforcement.
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影响因子：
3.4
作者：
CUNNINGHAM, KA;CALLAHAN, PM
通讯作者：
CALLAHAN, PM
DOI：
10.1196/annals.1300.023
发表时间：
2003-01-01
期刊：
GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION
影响因子：
--
作者：
Baker, DA;McFarland, K;Kalivas, PW
通讯作者：
Kalivas, PW
影响因子：
4.2
作者：
Comer, S. D.;Ashworth, J. B.;Walsh, S. L.
通讯作者：
Walsh, S. L.
影响因子：
3.6
作者：
Collins, ED;Vosburg, SK;Foltin, RW
通讯作者：
Foltin, RW
影响因子：
4.2
作者：
Chen, K;Scheier, LM;Kandel, DB
通讯作者：
Kandel, DB