Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type.
Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type.
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DOI：
10.1371/journal.pbio.3001677
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发表时间：
2022-06
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
--
作者：
单个气味的效价和显著性受动物的先天偏好、习得关联和内部状态以及气味呈现的环境的调节。气味价的环境依赖灵活性的机制尚未完全了解。在这里，我们展示了秀丽隐杆线虫对细菌产生的中链醇的行为反应，当在一组额外的有吸引力的化学物质的背景下出现时，从吸引到回避的转变。这种气味偏好的上下文依赖性逆转是由单个AWC嗅觉神经元对这些醇的反应的细胞自主反转驱动的。我们发现，虽然中链醇抑制AWC嗅觉神经元来驱动吸引力，但当出现第二种AWC感知的气味时，这些醇反而激活AWC来促进回避。我们发现这些相反的反应是通过AWC中不同的气味导向信号转导途径驱动的。我们的研究结果表明，在单一感觉神经元类型中，不同的细胞内信号通路的上下文依赖性募集传递相反的享乐价，从而为周围的气味编码和识别提供了一个强大的机制。本研究探讨了环境如何调节秀丽隐杆线虫中单个气味剂的价，揭示了单个感觉神经元类型中不同的细胞内信号通路的环境依赖性参与足以将嗅觉偏好行为从吸引转换为厌恶。
The valence and salience of individual odorants are modulated by an animal’s innate preferences, learned associations, and internal state, as well as by the context of odorant presentation. The mechanisms underlying context-dependent flexibility in odor valence are not fully understood. Here, we show that the behavioral response of Caenorhabditis elegans to bacterially produced medium-chain alcohols switches from attraction to avoidance when presented in the background of a subset of additional attractive chemicals. This context-dependent reversal of odorant preference is driven by cell-autonomous inversion of the response to these alcohols in the single AWC olfactory neuron pair. We find that while medium-chain alcohols inhibit the AWC olfactory neurons to drive attraction, these alcohols instead activate AWC to promote avoidance when presented in the background of a second AWC-sensed odorant. We show that these opposing responses are driven via engagement of distinct odorant-directed signal transduction pathways within AWC. Our results indicate that context-dependent recruitment of alternative intracellular signaling pathways within a single sensory neuron type conveys opposite hedonic valences, thereby providing a robust mechanism for odorant encoding and discrimination at the periphery. This study examines how context modulates the valence of individual odorants in the nematode Caenorhabditis elegans, revealing that context-dependent engagement of distinct intracellular signaling pathways within a single sensory neuron type is sufficient to switch olfactory preference behavior to an individual odorant from attraction to aversion.
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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