Control of methicillin resistant Staphylococcus aureus infection utilizing a novel immunostimulatory peptide.
Control of methicillin resistant Staphylococcus aureus infection utilizing a novel immunostimulatory peptide.
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DOI：
10.1016/j.vaccine.2011.10.054
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发表时间：
2011-12-09
期刊：
影响因子：
5.5
通讯作者：
Doran, Kelly S.
中科院分区：
文献类型：
--
作者：
Sheen, Tamsin R.;Cavaco, Courtney K.;Ebrahimi, Celia M.;Thoman, Marilyn L.;Sanderson, Sam D.;Morgan, Edward L.;Doran, Kelly S.
The emergence of community-acquired methicillin-resistant S. aureus (CA-MRSA) is a serious health concern worldwide that requires new therapeutic approaches that extend beyond the development and use of new antibiotics. In this study, a conformationally-biased, response-selective agonist of human C5a, known as EP67, was used to induce host innate immunity as a therapeutic method of reducing CA-MRSA infections. Using a murine model of dermonecrosis we show that EP67 treatment effectively limits CA-MRSA infection by promoting cytokine synthesis and neutrophil influx. In contrast, EP67 was ineffective in reducing lesion formation in C5a receptor (CD88-/-) knockout mice, indicating that EP67 activates host innate immunity by engagement of CD88 bearing cells. These results suggest that EP67 may serve as a novel immunotherapeutic for prevention and treatment of CA-MRSA dermal infection.
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影响因子：
5.5
作者：
Morgan, Edward L.;Thoman, Marilyn L.;Phillips, Joy A.
通讯作者：
Phillips, Joy A.
影响因子：
4.7
作者：
Phillips JA;Morgan EL;Dong Y;Cole GT;McMahan C;Hung CY;Sanderson SD
通讯作者：
Sanderson SD
影响因子：
3.2
作者：
PATTEE, PA
通讯作者：
PATTEE, PA
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
3.1
作者：
BUNCE, C;WHEELER, L;BARG, N
通讯作者：
BARG, N