Open Problems in Computational Vascular Biomechanics: Hemodynamics and Arterial Wall Mechanics.
Open Problems in Computational Vascular Biomechanics: Hemodynamics and Arterial Wall Mechanics.
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DOI：
10.1016/j.cma.2009.02.004
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发表时间：
2009-09-15
影响因子：
7.2
通讯作者：
Humphrey JD
中科院分区：
文献类型：
--
作者：
Taylor CA;Humphrey JD
血管系统由复杂的血管网络组成，包括大动脉、小动脉、毛细血管、小静脉和静脉。这一网络对于向组织提供氧气和营养物质以及从组织中清除二氧化碳和废物至关重要。由于其主要作用是压力驱动的化学机械运输系统，因此力学在正常血管系统的发展和维持以及血管疾病的进展和治疗中起着至关重要的作用就不足为奇了。这篇综述强调了过去在血管生物力学方面取得的一些成功，但强调需要综合分子生物学、生物力学、医学成像、计算方法和计算能力方面的互补进展，以增加我们对血管生理学和病理生理学的理解，并改进医疗设备和临床干预（包括外科手术）的设计。也就是说，计算力学对血管健康的持续改善有很大的希望。
The vasculature consists of a complex network of vessels ranging from large arteries to arterioles, capillaries, venules, and veins. This network is vital for the supply of oxygen and nutrients to tissues and the removal of carbon dioxide and waste products from tissues. Because of its primary role as a pressure-driven chemomechanical transport system, it should not be surprising that mechanics plays a vital role in the development and maintenance of the normal vasculature as well as in the progression and treatment of vascular disease. This review highlights some past successes of vascular biomechanics, but emphasizes the need for research that synthesizes complementary advances in molecular biology, biomechanics, medical imaging, computational methods, and computing power for purposes of increasing our understanding of vascular physiology and pathophysiology as well as improving the design of medical devices and clinical interventions, including surgical procedures. That is, computational mechanics has great promise to contribute to the continued improvement of vascular health.
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影响因子：
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作者：
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通讯作者：
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