Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy.
Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy.
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DOI：
10.1177/0300060517723183
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Iijima K
中科院分区：
文献类型：
--
作者：
Nagasaka H;Morioka I;Takuwa M;Nakacho M;Yoshida M;Ishida A;Hirayama S;Miida T;Tsukahara H;Yorifuji T;Iijima K
探讨基础氨基酸代谢和生长激素（GH）治疗对小于胎龄儿（矮小SGA儿童）的影响。在这项年龄匹配的病例对照研究中，比较了24名短SGA儿童和25名年龄匹配的正常儿童的氨基酸、不对称二甲基精氨酸（ADMA）和亚硝酸盐/硝酸盐（NOx）的基础血液水平。对12例开始GH治疗的矮小SGA儿童（A组）和12例未接受GH治疗的年龄匹配矮小SGA儿童（B组）进行了12个月的这些参数变化评估。短SGA组精氨酸水平明显低于正常儿童。短SGA组ADMA水平显著高于正常儿童，NOx水平显著低于正常儿童。在A组中，6个月时ADMA水平显著低于基线，NOx水平显著高于基线。12个月时，A组的ADMA水平开始增加，但NOx水平保持不变。B组无明显变化。这项研究是第一次表明，ADMA是促进和一氧化氮是抑制在短SGA儿童和生长激素治疗影响ADMA和一氧化氮的生产。
To investigate the basal amino acid metabolism and impact of growth hormone (GH) therapy in short-stature children born small for gestational age (short SGA children). In this age-matched case-control study, the basal blood levels of amino acids, asymmetric dimethylarginine (ADMA), and nitrite/nitrate (NOx) were compared between 24 short SGA children and 25 age-matched normal children. Changes in these parameters were assessed for 12 months in 12 short SGA children initiating GH therapy (Group A) and 12 age-matched short SGA children without GH therapy (Group B). The arginine levels were significantly lower in the short SGA than in normal children. The ADMA levels were significantly higher and NOx levels were significantly lower in the short SGA than normal children. In Group A, the ADMA level was significantly lower and NOx level was significantly higher at 6 months than at baseline. At 12 months, the ADMA level in Group A began to increase, but the NOx level remained the same. Group B showed no significant changes. This study is the first to show that ADMA is promoted and nitric oxide is suppressed in short SGA children and that GH therapy affects the production of ADMA and nitric oxide.
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DOI：
10.4274/jcrpe.1182
发表时间：
2014-01-01
影响因子：
1.9
作者：
Onder, Asan;Aycan, Zehra;Bas, Veysel Nijat
通讯作者：
Bas, Veysel Nijat
影响因子：
6.8
作者：
Schulze, F;Wesemann, R;Böger, RH
通讯作者：
Böger, RH
影响因子：
15.9
作者：
Boger, RH;Skamira, C;Frolich, JC
通讯作者：
Frolich, JC
影响因子：
3.2
作者：
Lebl, Jan;Lebenthal, Yael;Phillip, Moshe
通讯作者：
Phillip, Moshe
影响因子：
--
作者：
Cho WK;Suh BK
通讯作者：
Suh BK