Electroacupuncture alleviates affective pain in an inflammatory pain rat model.
Electroacupuncture alleviates affective pain in an inflammatory pain rat model.
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DOI：
10.1016/j.ejpain.2011.07.002
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Zhang RX
中科院分区：
文献类型：
--
作者：
Zhang Y;Meng X;Li A;Xin J;Berman BM;Lao L;Tan M;Ren K;Zhang RX
疼痛具有感觉辨别和情绪情感两个维度。以往的研究表明，电针（EA）的感觉维度，但不解决的情感。炎性疼痛大鼠模型，由完全弗氏佐剂（CFA）注射到后爪，结合条件性位置回避（CPA）测试，以确定是否EA抑制自发性疼痛诱导的情感反应，如果是这样，研究的可能性，喙前扣带皮层（rACC）阿片类药物的基础上这种效果。使用雄性Sprague-Dawley大鼠（250- 275 g，哈兰）。大鼠表现出位置厌恶（即情感性疼痛），在条件反射后，在疼痛配对隔室中花费的时间比在预处理测试期间少。全身非镇痛吗啡（0.5和1.0 mg/ kg，i. p.）抑制了情感反应，表明情感维度是由不同于疼痛的感觉维度的机制所支撑的。吗啡在0.5和1毫克/公斤没有引起奖励。在GB 30的疼痛配对条件反射之前给予EA治疗的大鼠对疼痛配对隔室没有表现出厌恶，表明EA抑制了情感维度。电针治疗没有产生奖励或厌恶效应。rACC内给予选择性μ阿片受体拮抗剂D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr酰胺（CTOP），但不给予选择性κ阿片受体拮抗剂norbinaltorphimine（nor-BNI），阻断了EA对情感维度的抑制。这些数据表明，EA激活阿片受体在rACC抑制疼痛引起的情感反应，EA可能是一种有效的治疗感觉歧视和情感方面的疼痛。
Pain has both sensory-discriminative and emotional-affective dimensions. Previous studies demonstrate that electroacupuncture (EA) alleviates the sensory dimension but do not address the affective. An inflammatory pain rat model, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a conditioned place avoidance (CPA) test to determine whether EA inhibits spontaneous pain-induced affective response and, if so, to study the possibility that rostral anterior cingulate cortex (rACC) opioids underlie this effect. Male Sprague-Dawley rats (250–275g, Harlan) were used. The rats showed place aversion (i.e. affective pain) by spending less time in a pain-paired compartment after conditioning than during a preconditioning test. Systemic non-analgesic morphine (0.5 and 1.0 mg/ kg, i.p.) inhibited the affective reaction, suggesting that the affective dimension is underpinned by mechanisms different from those of the sensory dimension of pain. Morphine at 0.5 and at 1 mg/kg did not induce reward. Rats given EA treatment before pain-paired conditioning at GB 30 showed no aversion to the pain-paired compartment, indicating that EA inhibited the affective dimension. EA treatment did not produce reward or aversive effect. Intra-rACC administration of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr amide (CTOP), a selective mu opioid receptor antagonist, but not norbinaltorphimine (nor-BNI), a selective kappa opioid receptor antagonist, blocked EA inhibition of the affective dimension. These data demonstrate that EA activates opioid receptors in the rACC to inhibit pain-induced affective responses and that EA may be an effective therapy for both the sensory-discriminative and the affective dimensions of pain.
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影响因子：
7.4
作者：
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通讯作者：
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DOI：
10.1073/pnas.96.14.7668
发表时间：
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影响因子：
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