Clinical correlates of depressive symptoms in familial Parkinson's disease.
Clinical correlates of depressive symptoms in familial Parkinson's disease.
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DOI：
10.1002/mds.22285
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发表时间：
2008-11-15
影响因子：
8.6
通讯作者：
Foroud, Tatiana
中科院分区：
文献类型：
--
作者：
Pankratz, Nathan;Marder, Karen S.;Halter, Cheryl A.;Rudolph, Alice;Shults, Cliff W.;Nichols, William C.;Foroud, Tatiana
抑郁症是帕金森病（PD）最常见的非运动并发症之一，对生活质量有重大影响。虽然有几个临床因素与抑郁症的PD，抑郁症和疾病阶段之间的关系，以及抑郁症和残疾程度之间的关系仍然存在争议。我们收集了来自632个家庭的1，378例PD病例的临床数据，使用统一帕金森病评定量表（UnitedParkinson’s Disease Rating Scale，简称PDRS）第二部分（日常生活活动）和第三部分（运动），简易精神状态检查，老年抑郁量表（GDS）和祝福功能活动量表（Blessed）。使用840名经验证的PD患者进行分析，没有认知能力下降的证据。Logistic回归用于确定单独和集体最佳预测抑郁症状（GDS ≥ 10）存在的研究变量。校正多项测试后，抑郁症状与Hoehn和Yahr分期和其他临床指标显著相关，但与任何遗传变异（parkin，LRRK 2，APOE）无关。Blessed评分、受教育程度、一级亲属是否有抑郁症状以及抑郁症患者抑郁量表第二部分被发现最能预测抑郁症患者（R2 = 0.33; P = 4 × 10−48）。与一些报告相反，这项大型研究的结果表明，疾病的阶段，运动障碍和功能障碍与抑郁症状密切相关。
Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10−48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.
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影响因子：
9.9
作者：
Foroud, T;Uniacke, SK;Nichols, WC
通讯作者：
Nichols, WC
影响因子：
2.6
作者：
Leentjens, AFG
通讯作者：
Leentjens, AFG
影响因子：
9.9
作者：
JANKOVIC, J;MCDERMOTT, M;WEINER, W
通讯作者：
WEINER, W
影响因子：
6
作者：
Liu, CY;Wang, SJ;Liu, HC
通讯作者：
Liu, HC
影响因子：
168.9
作者：
Nichols, WC;Pankratz, N;Foroud, T
通讯作者：
Foroud, T