Microbiota-targeted therapies: an ecological perspective.
Microbiota-targeted therapies: an ecological perspective.
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DOI：
10.1126/scitranslmed.3004183
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发表时间：
2012-06-06
影响因子：
17.1
通讯作者：
Fischbach MA
中科院分区：
文献类型：
--
作者：
Lemon KP;Armitage GC;Relman DA;Fischbach MA
疾病与宿主及其微生物群之间的稳态相互作用的破坏之间的联系现在已经很好地建立起来。药物开发人员和临床医生开始更多地依赖直接针对微生物群的疗法和微生物群的生态来了解这些治疗的结果。这些改变群落组成的微生物群靶向疗法的效果范围从消除单一物种的个体菌株（例如，使用抗菌缀合物疫苗）到用新的完整微生物群取代整个群落（例如，通过粪便移植）。与抗生素使用相关的继发性感染提供了一个关于扰乱微生物物种网络的意外后果的警示故事，并强调了对新的窄谱抗生素和快速伴随诊断的需求。对微生物生态学的深入了解也将有利于益生菌的发展，其治疗前景将取决于严格的临床测试。未来的益生菌可能会采取长期社区居民财团的形式：“胶囊中的粪便移植”。微生物群靶向治疗的疗效需要使用新的诊断工具来评估，这些工具测量群落功能而不是组成，包括微生物群落对确定的扰动（如抗生素或益生菌）的时间响应。
The connection between disease and the disruption of homeostatic interactions between the host and its microbiota is now well established. Drug developers and clinicians are starting to rely more heavily on therapies that directly target the microbiota and on the ecology of the microbiota to understand the outcomes of these treatments. The effects of those microbiota-targeted therapies that alter community composition range in scale from eliminating individual strains of a single species (for example, with antibacterial conjugate vaccines) to replacing the entire community with a new intact microbiota (for example, by fecal transplantation). Secondary infections linked to antibiotic use provide a cautionary tale of the unintended consequences of perturbing a microbial species network and highlight the need for new narrow-spectrum antibiotics with rapid companion diagnostics. Insights into microbial ecology will also benefit the development of probiotics, whose therapeutic prospects will depend on rigorous clinical testing. Future probiotics may take the form of a consortium of long-term community residents: “a fecal transplant in a capsule.” The efficacy of microbiota-targeted therapies will need to be assessed using new diagnostic tools that measure community function rather than composition, including the temporal response of a microbial community to a defined perturbation such as an antibiotic or probiotic.
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DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
3
作者：
Hayashi, F;Okada, M;Kozai, K
通讯作者：
Kozai, K
影响因子：
56.9
作者：
Haydon, David J.;Stokes, Neil R.;Czaplewski, Lloyd G.
通讯作者：
Czaplewski, Lloyd G.
影响因子：
3.2
作者：
Denou, Emmanuel;Pridmore, Raymond David;Bruessow, Harald
通讯作者：
Bruessow, Harald