The application of ecological theory toward an understanding of the human microbiome.
The application of ecological theory toward an understanding of the human microbiome.
复制标题
DOI：
10.1126/science.1224203
复制
发表时间：
2012-06-08
期刊：
影响因子：
--
通讯作者：
Relman DA
中科院分区：
文献类型：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
人类微生物生态系统在人类健康和疾病中发挥着多种作用。每个个体都可以被看作是由群落生态学的基本过程（即扩散、局部多样化、环境选择和生态漂变）形成的微生物群落所占据的一个岛屿般的栖息地“斑块”。在这篇综述中，我们考虑如何使用群落组装理论，例如，元群落理论，来帮助解释人类微生物组的动态，特别是宿主内部和宿主之间的组成变异性。我们探讨了人类微生物组组装的三个核心场景：婴儿的发育，代表了以前无人居住的栖息地的组装；从抗生素中恢复，代表干扰后的组装；病原体的入侵，代表了入侵物种的集合。明智地应用生态学理论可能会改善维持和恢复微生物群的策略，以及它提供的与健康相关的关键生态系统服务。
The human microbial ecosystem plays a diversity of roles in human health and disease. Each individual can be viewed as an island-like “patch” of habitat occupied by microbial assemblages formed by the fundamental processes of community ecology, i.e., dispersal, local diversification, environmental selection, and ecological drift. In this review, we consider how community assembly theory, and as an example, metacommunity theory, could be used to help explain the dynamics of the human microbiome, and in particular, compositional variability within and between hosts. We explore three core scenarios of human microbiome assembly: development in infants, representing assembly in previously unoccupied habitat; recovery from antibiotics, representing assembly after disturbance; and invasion by pathogens, representing assembly in the context of invasive species. Judicious application of ecological theory may lead to improved strategies for maintaining and restoring the microbiota, and the crucial health-associated ecosystem services that it provides.
登录
查看更多内容
影响因子：
6.4
作者：
BOHNHOFF, M;MILLER, CP
通讯作者：
MILLER, CP
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
17.1
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
通讯作者：
Ravel J
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi