Enhancing recovery from peripheral nerve injury using treadmill training.
Enhancing recovery from peripheral nerve injury using treadmill training.
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DOI：
10.1016/j.aanat.2011.02.013
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发表时间：
2011-07
影响因子：
2.2
通讯作者：
Sabatier, Manning J.
中科院分区：
文献类型：
--
作者：
English, Arthur W.;Wilhelm, Jennifer C.;Sabatier, Manning J.
创伤性周围神经损伤后的完全功能恢复是罕见的。我们假设观察到的功能结局指标较差的三个原因。轴突再生是缓慢的，并不是所有的轴突参与。发生再生轴突的显著错误方向以重新神经支配不适当的目标。在中枢神经系统的神经回路似乎永久性的变化被发现伴随着周围轴突的轴突切断。每天适度的跑步机训练会影响这三个方面。与未经训练的对照组相比，在跑步机训练的动物中再生轴突延长得更远，并且通过自分泌/旁分泌神经营养因子信号通路来实现。这种轴突再生的增强发生在没有训练的再生轴突的错误方向量没有增加的情况下。这种增强也以性别依赖的方式发生。缓慢的持续训练仅对男性有效，而更激烈的间歇训练仅对女性有效。在跑步机训练，但不是未经训练的小鼠的轴突切断运动神经元的覆盖范围保持，从而保留脊髓回路的重要元素。
Full functional recovery after traumatic peripheral nerve injury is rare. We postulate three reasons for the poor functional outcome measures observed. Axon regeneration is slow and not all axons participate. Significant misdirection of regenerating axons to reinnervate inappropriate targets occurs. Seemingly permanent changes in neural circuitry in the central nervous system are found to accompany axotomy of peripheral axons. Exercise in the form of modest daily treadmill training impacts all three of these areas. Compared to untrained controls, regenerating axons elongate considerably farther in treadmill trained animals and do so via an autocrine/paracrine neurotrophin signaling pathway. This enhancement of axon regeneration takes place without an increase in the amount of misdirection of regenerating axons found without training. The enhancement also occurs in a sex-dependent manner. Slow continuous training is effective only in males, while more intense interval training is effective only in females. In treadmill trained, but not untrained mice the extent of coverage of axotomized motoneurons is maintained, thus preserving important elements of the spinal circuitry.
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影响因子：
5.2
作者：
Alvarez FJ;Bullinger KL;Titus HE;Nardelli P;Cope TC
通讯作者：
Cope TC
影响因子：
5.3
作者：
Davis-Lopez de Carrizosa, Maria A.;Morado-Diaz, Camilo J.;Pastor, Angel M.
通讯作者：
Pastor, Angel M.
影响因子：
5.3
作者：
de Carrizosa, Maria A. Davis-Lopez;Morado-Diaz, Camilo J.;Pastor, Angel M.
通讯作者：
Pastor, Angel M.
DOI：
10.1007/bf00325030
发表时间：
1968-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
BLINZING.K;KREUTZBE.G
通讯作者：
KREUTZBE.G
影响因子：
4.2
作者：
Engesser-Cesar, C;Anderson, AJ;Cotman, CW
通讯作者：
Cotman, CW