The association between physical activity and renal cancer: systematic review and meta-analysis.
The association between physical activity and renal cancer: systematic review and meta-analysis.
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DOI：
10.1038/bjc.2013.37
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发表时间：
2013-03-05
影响因子：
8.8
通讯作者：
Leitzmann MF
中科院分区：
文献类型：
--
作者：
Behrens G;Leitzmann MF
体力活动可以通过减少肥胖、血压、胰岛素抵抗和脂质过氧化来降低肾癌风险。尽管有合理的生物学机制将体力活动增加与肾癌风险降低联系起来，但很少有流行病学研究能够报告体力活动与肾癌之间存在明确的负相关性，并且没有关于该主题的荟萃分析。我们使用PubMed和Web of Knowledge检索文献，以确定已发表的非生态流行病学研究，这些研究量化了无癌症史个体的体力活动与肾癌风险之间的关系。根据PRISMA指南，我们进行了系统回顾和荟萃分析，包括19项研究的信息，共2327322例受试者和10756例病例。使用综合评分系统检查研究的方法学质量。比较高水平和低水平的体力活动，我们观察到体力活动和肾癌风险之间的负相关（随机效应荟萃分析的汇总相对风险（RR）=0.88; 95%置信区间（CI）=0.79-0.97）。从高质量研究中总结的风险估计加强了体力活动和肾癌风险之间的负相关性（RR=0.78; 95%CI =0.66-0.92）。未观察到肥胖、高血压、2型糖尿病、吸烟、性别或地理区域的影响。我们的综合荟萃分析为体力活动与肾癌风险的反比关系提供了强有力的支持。未来需要进行高质量的研究，以确定降低肾癌风险需要哪些特定类型，强度，频率和持续时间的体力活动。
Physical activity may decrease renal cancer risk by reducing obesity, blood pressure, insulin resistance, and lipid peroxidation. Despite plausible biologic mechanisms linking increased physical activity to decreased risk for renal cancer, few epidemiologic studies have been able to report a clear inverse association between physical activity and renal cancer, and no meta-analysis is available on the topic. We searched the literature using PubMed and Web of Knowledge to identify published non-ecologic epidemiologic studies quantifying the relationship between physical activity and renal cancer risk in individuals without a cancer history. Following the PRISMA guidelines, we conducted a systematic review and meta-analysis, including information from 19 studies based on a total of 2 327 322 subjects and 10 756 cases. The methodologic quality of the studies was examined using a comprehensive scoring system. Comparing high vs low levels of physical activity, we observed an inverse association between physical activity and renal cancer risk (summary relative risk (RR) from random-effects meta-analysis=0.88; 95% confidence interval (CI)=0.79–0.97). Summarising risk estimates from high-quality studies strengthened the inverse association between physical activity and renal cancer risk (RR=0.78; 95% CI=0.66–0.92). Effect modification by adiposity, hypertension, type 2 diabetes, smoking, gender, or geographic region was not observed. Our comprehensive meta-analysis provides strong support for an inverse relation of physical activity to renal cancer risk. Future high-quality studies are required to discern which specific types, intensities, frequencies, and durations of physical activity are needed for renal cancer risk reduction.
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影响因子：
50.5
作者：
Boyle, P;Ferlay, J
通讯作者：
Ferlay, J
影响因子：
5.8
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Eliakim, A;Brasel, JA;Cooper, DM
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作者：
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通讯作者：
Matthews, Charles E.
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2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
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