Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocae.
Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocae.
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DOI：
10.3390/md13010276
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发表时间：
2015-01-07
期刊：
影响因子：
5.4
通讯作者：
Wang BG
中科院分区：
文献类型：
--
作者：
Meng LH;Zhang P;Li XM;Wang BG
从褐青霉MA-231的培养提取物中分离和鉴定了5个新的硫化二酮并四氮类化合物，即青霉素A-E(1-5)和一个已知的同系物(6)。化合物1和3的结构经核磁共振和质谱学确证，并经单晶X-射线衍射法确证。对所有化合物进行了细胞毒性和抗菌活性检测。化合物2-6对部分供试菌株表现出一定的抑菌活性，其MIC值在0.25MIC值~μg/mL之间。
Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2–6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL.
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