A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.
A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.
复制标题
DOI：
10.1289/ehp.98106385
复制
发表时间：
1998-07
影响因子：
10.4
通讯作者：
Hainaut P
中科院分区：
文献类型：
--
作者：
Hernandez-Boussard TM;Hainaut P
p53基因突变在肺癌中很常见。使用国际癌症研究机构p53突变数据库（R1）的数据，我们分析了文献中描述的876例肺肿瘤中p53突变的分布和性质。这些分析证实，G到T转换是吸烟者肺癌中p53突变的主要类型。最常突变的密码子包括157、158、179、248、249和273，其中几个（157、248和273）已被证明对应于多环芳烃（PAH）如苯并（a）芘的代谢物在体外形成DNA加合物的位点。此外，肺癌中密码子248、249和273处的大多数碱基变化与数据库中报告的其他癌症中这些密码子处通常观察到的碱基变化不同。因此，吸烟者的肺癌显示出独特的p53突变谱，这在非吸烟者的肺癌中没有观察到。这些结果进一步加强了主动吸烟，暴露于多环芳烃和肺癌之间的联系。他们还表明，在不吸烟者中发生了不同的突变模式，这一观察可能有助于确定与不吸烟者肺癌因果相关的其他因素。
Mutations in the p53 gene are common in lung cancer. Using data from the the International Agency for Research on Cancer p53 mutation database (R1), we have analyzed the distribution and nature of p53 mutations in 876 lung tumors described in the literature. These analyses confirm that G to T transitions are the predominant type of p53 mutation in lung cancer from smokers. The most frequently mutated codons include 157, 158, 179, 248, 249, and 273, and several of them (157, 248, and 273) have been shown to correspond to sites of in vitro DNA adduct formation by metabolites of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene. Furthermore, most of the base changes at codons 248, 249, and 273 in lung cancer differ from those commonly observed at these codons in other cancers reported in the database. Thus, lung cancer from smokers shows a distinct, unique p53 mutation spectrum that is not observed in lung cancer from nonsmokers. These results further strengthen the association between active smoking, exposure to PAHs, and lung cancer. They also indicate that a different pattern of mutations occurs in nonsmokers, and this observation may help to identify other agents causally involved in lung cancer in nonsmokers.
登录
查看更多内容
影响因子：
8
作者：
Denissenko, MF;Pao, A;Tang, MS
通讯作者：
Tang, MS
影响因子：
14.9
作者：
Hainaut, P;Hernandez, T;Montesano, R
通讯作者：
Montesano, R
影响因子：
4.7
作者：
Kure, EH;Ryberg, D;Haugen, A
通讯作者：
Haugen, A
影响因子：
3.5
作者：
ESSIGMANN, JM;WOOD, ML
通讯作者：
WOOD, ML
影响因子：
10.4
作者：
HusgafvelPursiainen, K;Kannio, A
通讯作者：
Kannio, A