Experimental endoretinal biopsy.
Experimental endoretinal biopsy.
复制标题
实验性视网膜内活检。
DOI：
10.1016/s0002-9394(14)77058-8
复制
发表时间：
1990
影响因子：
4.2
通讯作者：
Freeman,WR
中科院分区：
文献类型：
--
作者：
Gross,JG;Schneiderman,TE;Wiley,CA;Bergeron-Lynn,G;Faber,DW;Freeman,WR
我们在兔眼进行了经玻璃体视网膜内活检，以发展一种可靠和安全的技术，从附着的视网膜获得视网膜标本。玻璃体切除术后不进行晶状体切除术，然后将林格氏液注射到视网膜下腔以产生局灶性视网膜脱离。用眼内剪刀切除局灶性脱离的顶点，并通过气动液压排出从眼内取出。一次液体-空气交换使视网膜复位。术后20周内定期对活检部位进行临床评价，并进行光学和电子显微镜检查。最初的五次手术在输注液中没有肝素的情况下进行，并且并发了严重的纤维蛋白反应和早期视网膜脱离。其余17只眼中，15只无术中并发症，视网膜保持附着。活检部位沿边缘沿着出现早期色素沉着环，由于细胞质增生和色素上皮肥大，活检床色素沉着逐渐增加。组织学上观察到视网膜前膜和视网膜下新生血管。视网膜活检标本是可重复的，适合诊断研究。
We performed transvitreal endoretinal biopsy in rabbit eyes to develop a reliable and safe technique to obtain retinal specimens from attached retina. Pars plana vitrectomy without lensectomy was followed by injection of Ringer's solution into the subretinal space to produce a focal retinal detachment. The apex of the focal detachment was excised by intraocular scissors and removed from the eye by pneumohydraulic expulsion. A fluid-air exchange reattached the retina. The biopsy sites were evaluated clinically and by light and electron microscopy at regular intervals up to 20 weeks postoperatively. The initial five procedures were performed without heparin in the infusion fluid, and they were complicated by severe fibrin reaction and early retinal detachment. Of the remaining 17 eyes, 15 were without intraoperative complication and maintained attached retinas. The biopsy site developed an early ring of hyperpigmentation along the border, and the biopsy bed became increasingly hyperpigmented because of cytoplasmic hyperplasia and hypertrophy of the pigment epithelium. Epiretinal membranes and subretinal neovascularization were observed histologically. Retinal biopsy specimens were reproducible and suitable for diagnostic studies.
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脉络膜视网膜活检的问题1
影响因子：
17.3
作者：
I. Constable
通讯作者：
I. Constable
兔子实验性视网膜切除术
DOI：
10.1097/00006982-199001010-00014
发表时间：
1990
期刊：
Retina
影响因子：
--
作者：
R. Hutchins;D. D’Amico;VO;Brian Morin
通讯作者：
Brian Morin
肝素预防眼内纤维蛋白。
影响因子：
13.7
作者：
Johnson,RN;Balyeat,E;Stern,WH
通讯作者：
Stern,WH
水痘带状疱疹病毒是急性视网膜坏死综合征的病因。
影响因子：
13.7
作者：
W. Culbertson;M. Blumenkranz;J. Pepose;J. Stewart;V. Curtin
通讯作者：
V. Curtin
通过活检获得的视网膜对研究的潜在用途。
影响因子：
4.4
作者：
Bird,AC;Farber,DB;Kreiger,AE;Straatsma,BR;Bok,D
通讯作者：
Bok,D