Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.
复制标题
DOI：
10.1016/j.celrep.2014.07.030
复制
发表时间：
2014-09-11
期刊：
影响因子：
8.8
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Fang X;Seim I;Huang Z;Gerashchenko MV;Xiong Z;Turanov AA;Zhu Y;Lobanov AV;Fan D;Yim SH;Yao X;Ma S;Yang L;Lee SG;Kim EB;Bronson RT;Šumbera R;Buffenstein R;Zhou X;Krogh A;Park TJ;Zhang G;Wang J;Gladyshev VN
地下哺乳动物生活在黑暗、不通风、富含二氧化碳和氨、低氧的环境中。这些动物中的许多也很长寿，并表现出较少的与衰老相关的疾病，如神经退行性疾病和癌症。我们对达玛兰鼹鼠（DMR, Fukomys damarensis）的基因组进行了测序，并对裸鼹鼠（NMR, Heterocephalus glaber）的基因组组装进行了改进。比较基因组分析，以及相关地下啮齿动物的转录组，揭示了地下生活和长寿的候选分子适应，包括胰岛素肽的分化，大脑中携带氧气的球蛋白的表达，防止高二氧化碳诱导的疼痛感知，以及增强氨解毒。将DMR和其他更传统的动物基因组与NMR基因组并置，揭示了几个真正特殊的NMR特征：不寻常的产热，异常的褪黑激素系统，疼痛不敏感和28S rRNA的新处理。总之，新的基因组和转录组扩展了我们对地下适应、抗逆性和寿命的理解。
Subterranean mammals spend their lives in dark, unventilated environments rich in carbon dioxide and ammonia, and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging-associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaraland mole rat (DMR, Fukomys damarensis) and improved the genome assembly of the naked mole rat (NMR, Heterocephalus glaber). Comparative genome analysis, along with transcriptomes of related subterranean rodents, reveal candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression of oxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, aberrant melatonin system, pain insensitivity, and novel processing of 28S rRNA. Together, the new genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance and longevity.
登录
查看更多内容
影响因子：
3.3
作者：
Aksenov, MY;Aksenova, MV;Markesbery, WR
通讯作者：
Markesbery, WR
影响因子：
3.9
作者：
Edrey, Yael H.;Park, Thomas J.;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle
影响因子：
3.7
作者：
Azpurua J;Seluanov A
通讯作者：
Seluanov A
影响因子：
5.2
作者：
Blagosklonny, Mikhail V.
通讯作者：
Blagosklonny, Mikhail V.
影响因子：
4.8
作者：
Fiermonte, G;Dolce, V;Walker, JE
通讯作者：
Walker, JE