The snail family gene snai3 is not essential for embryogenesis in mice.
The snail family gene snai3 is not essential for embryogenesis in mice.
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DOI：
10.1371/journal.pone.0065344
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gridley T
中科院分区：
文献类型：
--
作者：
Bradley CK;Norton CR;Chen Y;Han X;Booth CJ;Yoon JK;Krebs LT;Gridley T
蜗牛基因家族编码含锌指的转录抑制蛋白。在哺乳动物中已经发现了蜗牛基因家族的三个成员，分别由Snai1、Snai2和Snai3基因编码。Snai1和Snai2基因在脊椎动物胚胎发生和肿瘤进展转移过程中的功能已被广泛研究，并在这些过程中起着至关重要的作用。然而，人们对Snai3基因及其蛋白的功能知之甚少。我们在这里描述了Snai3条件和零突变小鼠的产生和分析。我们还生成了一个eyfp标记的Snai3空等位基因，该等位基因准确反映了内源性Snai3基因的表达，在胸腺和骨骼肌中检测到最高的表达水平。Snai3零突变纯合子小鼠存活且可育，无明显表型缺陷。这些结果表明Snai3基因的功能在小鼠胚胎发生中不是必需的。
The Snail gene family encodes zinc finger-containing transcriptional repressor proteins. Three members of the Snail gene family have been described in mammals, encoded by the Snai1, Snai2, and Snai3 genes. The function of the Snai1 and Snai2 genes have been studied extensively during both vertebrate embryogenesis and tumor progression and metastasis, and play critically important roles during these processes. However, little is known about the function of the Snai3 gene and protein. We describe here generation and analysis of Snai3 conditional and null mutant mice. We also generated an EYFP-tagged Snai3 null allele that accurately reflects endogenous Snai3 gene expression, with the highest levels of expression detected in thymus and skeletal muscle. Snai3 null mutant homozygous mice are viable and fertile, and exhibit no obvious phenotypic defects. These results demonstrate that Snai3 gene function is not essential for embryogenesis in mice.
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影响因子：
10.5
作者：
SWIATEK, PJ;GRIDLEY, T
通讯作者：
GRIDLEY, T
DOI：
10.1073/pnas.0602234103
发表时间：
2006-07-05
影响因子：
11.1
作者：
Murray, Stephen A.;Gridley, Thomas
通讯作者：
Gridley, Thomas
影响因子：
4.8
作者：
Zhao, P;Iezzi, S;Hoffman, EP
通讯作者：
Hoffman, EP
影响因子：
1.2
作者：
Liedtke, Daniel;Erhard, Isabell;Schartl, Manfred
通讯作者：
Schartl, Manfred
影响因子：
5.4
作者：
Dahlem, Timothy;Cho, Scott;Spangrude, Gerald J.;Weis, Janis J.;Weis, John H.
通讯作者：
Weis, John H.