Genetic characterization of an H2N2 influenza virus isolated from a muskrat in Western Siberia.

Genetic characterization of an H2N2 influenza virus isolated from a muskrat in Western Siberia.
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从西伯利亚西部的麝香鼠中分离出的H2N2流感病毒的遗传表征。

DOI:
10.1292/jvms.17-0048
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发表时间:
2017-08-18
期刊:
The Journal of veterinary medical science
影响因子:
--
通讯作者:
Shestopalov A
Shestopalov A
中科院分区:
其他
文献类型:
--
作者:
Gulyaeva M;Sharshov K;Suzuki M;Sobolev I;Sakoda Y;Alekseev A;Sivay M;Shestopalova L;Shchelkanov M;Shestopalov A

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俄罗斯西西伯利亚恰尼湖附近捕获了 32 只麝香鼠 (Ondatra zibethicus),用于监测野生水禽和哺乳动物中的禽流感病毒。 A/muskrat/Russia/63/2014 (H2N2) 是使用鸡胚从一只表面健康的麝香鼠中分离出来的。根据系统发育分析,该分离株的血凝素和神经氨酸酶基因属于欧亚类禽流感病毒进化枝,并分别与从意大利和瑞典野生水鸟中分离到的低致病性禽流感病毒(LPAIV)密切相关。其他内部基因也与从欧亚野生水鸟中分离出的 LPAIV 密切相关。结果表明,LPAIV 存在从野生水鸟到半水生哺乳动物的种间传播,促进了 LPAIV 在西西伯利亚湿地地区的传播和进化。
Thirty-two muskrats (Ondatra zibethicus) were captured for surveillance of avian influenza virus in wild waterfowl and mammals near Lake Chany, Western Siberia, Russia. A/muskrat/Russia/63/2014 (H2N2) was isolated from an apparently healthy muskrat using chicken embryos. Based on phylogenetic analysis, the hemagglutinin and neuraminidase genes of this isolate were classified into the Eurasian avian-like influenza virus clade and closely related to low pathogenic avian influenza viruses (LPAIVs) isolated from wild water birds in Italy and Sweden, respectively. Other internal genes were also closely related to LPAIVs isolated from Eurasian wild water birds. Results suggest that interspecies transmission of LPAIVs from wild water birds to semiaquatic mammals occurs, facilitating the spread and evolution of LPAIVs in wetland areas of Western Siberia.
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