Connecting the study of wild influenza with the potential for pandemic disease.

Connecting the study of wild influenza with the potential for pandemic disease.
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DOI:
10.1016/j.meegid.2013.02.020
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发表时间:
2013-07
期刊:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子:
--
通讯作者:
Keogh M
Keogh M
中科院分区:
其他
文献类型:
--
作者:
Runstadler J;Hill N;Hussein IT;Puryear W;Keogh M

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致病性 (H5N1) 和大流行性 (SOIVH1N1) 流感的持续爆发凸显了了解对人类健康构成威胁的新型甲型流感病毒 (IAV) 变种的起源、特征和进化的必要性。在过去的 4-5 年里,重点放在组织大规模监测计划上,以检查禽流感病毒 (AIV) 的系统发育以及家养和野生动物的宿主-病毒关系。在这里,我们回顾了目前野生动物和环境监测方面的差距以及目前对潜在大流行菌株遗传特征的理解。
Continuing outbreaks of pathogenic (H5N1) and pandemic (SOIVH1N1) influenza have underscored the need to understand the origin, characteristics, and evolution of novel influenza A virus (IAV) variants that pose a threat to human health. In the last 4–5 years, focus has been placed on the organization of large-scale surveillance programs to examine the phylogenetics of avian influenza virus (AIV) and host-virus relationships in domestic and wild animals. Here we review the current gaps in wild animal and environmental surveillance and the current understanding of genetic signatures in potentially pandemic strains.
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