Impact of prediabetic status on coronary atherosclerosis: a multivessel angioscopic study.
Impact of prediabetic status on coronary atherosclerosis: a multivessel angioscopic study.
复制标题
DOI：
10.2337/dc12-1635
复制
发表时间：
2013-03
期刊：
影响因子：
16.2
通讯作者：
Mizuno K
中科院分区：
文献类型：
--
作者：
Kurihara O;Takano M;Yamamoto M;Shirakabe A;Kimata N;Inami T;Kobayashi N;Munakata R;Murakami D;Inami S;Okamatsu K;Ohba T;Ibuki C;Hata N;Seino Y;Mizuno K
为了确定糖尿病前期是否与冠状动脉粥样硬化相关，我们通过使用冠状动脉血管镜检查评估非糖尿病、糖尿病前期和糖尿病患者的冠状动脉粥样硬化程度，以基于黄色强度识别斑块易损性。对67例冠心病患者进行了多支主干冠状动脉的血管镜观察。根据美国糖尿病协会指南，患者分为非糖尿病组（n = 16）、糖尿病前期组（n = 28）和糖尿病组（n = 23）。根据血管镜检查结果，斑块颜色等级定义为1（浅黄色）、2（黄色）或3（深黄色）。比较各组间每支血管的黄色斑块数（NYP）和最大黄色等级（MYG）。两组间平均NYP和MYG差异显著（分别为P = 0.01和P = 0.047）。这些指标在糖尿病前期患者中高于非糖尿病患者（分别为P = 0.02和P = 0.04），但在糖尿病前期和糖尿病患者中相似（分别为P = 0.44和P = 0.21）。在多变量logistic回归分析中，糖尿病和糖尿病前期是多发性黄色斑块（NYP ≥2）的独立预测因子（比值比[OR] 10.8 [95%CI 2.09-55.6]，P = 0.005; OR 4.13 [95%CI 1.01-17.0]，P = 0.049）。糖尿病前期患者冠状动脉粥样硬化和斑块易损性比非糖尿病患者更严重，糖尿病前期患者和糖尿病患者之间具有可比性。轻微或轻度的葡萄糖代谢紊乱，如前驱糖尿病，可能是CAD的危险因素，糖尿病本身也是如此。
To determine if prediabetes is associated with atherosclerosis of coronary arteries, we evaluated the degree of coronary atherosclerosis in nondiabetic, prediabetic, and diabetic patients by using coronary angioscopy to identify plaque vulnerability based on yellow color intensity. Sixty-seven patients with coronary artery disease (CAD) underwent angioscopic observation of multiple main-trunk coronary arteries. According to the American Diabetes Association guidelines, patients were divided into nondiabetic (n = 16), prediabetic (n = 28), and diabetic (n = 23) groups. Plaque color grade was defined as 1 (light yellow), 2 (yellow), or 3 (intense yellow) based on angioscopic findings. The number of yellow plaques (NYPs) per vessel and maximum yellow grade (MYG) were compared among the groups. Mean NYP and MYG differed significantly between the groups (P = 0.01 and P = 0.047, respectively). These indexes were higher in prediabetic than in nondiabetic patients (P = 0.02 and P = 0.04, respectively), but similar in prediabetic and diabetic patients (P = 0.44 and P = 0.21, respectively). Diabetes and prediabetes were independent predictors of multiple yellow plaques (NYPs ≥2) in multivariate logistic regression analysis (odds ratio [OR] 10.8 [95% CI 2.09–55.6], P = 0.005; and OR 4.13 [95% CI 1.01–17.0], P = 0.049, respectively). Coronary atherosclerosis and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable between prediabetic and diabetic patients. Slight or mild disorders in glucose metabolism, such as prediabetes, could be a risk factor for CAD, as is diabetes itself.
登录
查看更多内容
影响因子：
16.2
作者：
通讯作者：
--
影响因子：
3.3
作者：
Yamamoto, Masanori;Takano, Masamichi;Mizuno, Kyoichi
通讯作者：
Mizuno, Kyoichi
影响因子：
16.2
作者：
Kataoka, Y;Yasuda, S;Miyazaki, S
通讯作者：
Miyazaki, S
影响因子：
24
作者：
Virmani, R;Burke, AP;Kolodgie, FD
通讯作者：
Kolodgie, FD
影响因子：
24
作者：
Ohtani, Tomohito;Ueda, Yasunori;Kodama, Kazuhisa
通讯作者：
Kodama, Kazuhisa